Evidence map›Paper›PMID 22332093›Full record

ReviewAdvances in nutrition (Bethesda, Md.)2011

Translational regulation in nutrigenomics.

Botao Liu, Shu-Bing Qian

Open access · bronzeAbstract readReview
In one paragraph

Review in Advances in nutrition (Bethesda, Md.), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 55 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Polymorphisms, diet and nutrigenomics.Journal of preventive medicine and hygiene · 2022
    Review
  5. Review
  6. Review
  7. Review
  8. Article
  9. Nutrigenomics: definitions and advances of this new science.Journal of nutrition and metabolism · 2014
    Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Botao LiuGraduate Field of Genetics and Development, Division of Nutritional Sciences, Cornell University, Ithaca, NY 14853, USA.
Shu-Bing Qian
Cornell University · US

Funding

Engineering Ubiquitin Ligases to Investigate Protein Aggregation and NeurodegenerDP2OD006449 · OD · CORNELL UNIVERSITY · PI QIAN, SHU-BING · 2009 to 2009
$2.3M
NIH HHS 1DP2 OD006449-01NIH HHS DP2 OD006449
6 · The paper itself

Abstract

The emergence of genome-wide analysis to interrogate cellular DNA, RNA, and protein content has revolutionized the study of the control network that mediates cellular homeostasis. Nutrigenomics addresses the effect of nutrients on gene expression, which provides a basis for understanding the biological activity of dietary components. Translation of mRNAs represents the last step of genetic flow and primarily defines the proteome. Translational regulation is thus critical for gene expression, in particular, under nutrient excess or deficiency. Until recently, it was unclear how the global effects of translational control are influenced by nutrient signaling. An emerging concept of translational reprogramming addresses how to maintain the expression of specific proteins during pathophysiological conditions by translation of selective mRNAs. Here we describe recent advances in our understanding of translational control, nutrient signaling, and their dysregulation in aging and cancer. The mechanistic understanding of translational regulation in response to different nutrient conditions may help identify potential dietary and therapeutic targets to improve human health.

Indexed as

NutrigenomicsAgingAmino AcidsGene Expression RegulationHumansNeoplasmsProtein BiosynthesisAmino Acids

Identifiers

PMID22332093
PMCPMC3226388
OpenAlexW2103975024

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.