Evidence map›Paper›PMID 22332087›Full record

ReviewAdvances in nutrition (Bethesda, Md.)2011

Emerging perspectives on essential amino acid metabolism in obesity and the insulin-resistant state.

Sean H Adams

Open access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Advances in nutrition (Bethesda, Md.), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 219 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
219citing papers in PubMed, 6 pooled it
10.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

219 citing papers in PubMed, 6 syntheses or guidelines pooled it, 399 citations in OpenAlex.

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159 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Sean H AdamsObesity and Metabolism Research Unit, USDA Agricultural Research Service Western Human Nutrition Research Center, and Department of Nutrition, University of California, Davis, CA, USA. sean.h.adams@ars.usda.gov
Agricultural Research Service · US

Funding

Identification of Muscle-Specific Biomarkers of Fatty Acid beta-OxidationR01DK078328 · NIDDK · U.S. AGRICULTURAL RESEARCH SERVICE · PI ADAMS, SEAN HARRISON · 2008 to 2012
$1.8M
NIDDK NIH HHS R01 DK078328NIDDK NIH HHS R01DK078328-01NIDDK NIH HHS R01DK078328-02S
6 · The paper itself

Abstract

Dysregulation of insulin action is most often considered in the context of impaired glucose homeostasis, with the defining feature of diabetes mellitus being elevated blood glucose concentration. Complications arising from the hyperglycemia accompanying frank diabetes are well known and epidemiological studies point to higher risk toward development of metabolic disease in persons with impaired glucose tolerance. Although the central role of proper blood sugar control in maintaining metabolic health is well established, recent developments have begun to shed light on associations between compromised insulin action [obesity, prediabetes, and type 2 diabetes mellitus (T2DM)] and altered intermediary metabolism of fats and amino acids. For amino acids, changes in blood concentrations of select essential amino acids and their derivatives, in particular BCAA, sulfur amino acids, tyrosine, and phenylalanine, are apparent with obesity and insulin resistance, often before the onset of clinically diagnosed T2DM. This review provides an overview of these changes and places recent observations from metabolomics research into the context of historical reports in the areas of biochemistry and nutritional biology. Based on this synthesis, a model is proposed that links the FFA-rich environment of obesity/insulin resistance and T2DM with diminution of BCAA catabolic enzyme activity, changes in methionine oxidation and cysteine/cystine generation, and tissue redox balance (NADH/NAD+).

Indexed as

3-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide)Amino Acids, AromaticAmino Acids, SulfurAnimalsCysteineCystineDiabetes Mellitus, Type 2HumansInsulin ResistanceMethionineModels, BiologicalObesityOxidation-ReductionOxidative StressPhenylalanineTransaminases3-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide)Amino Acids, AromaticAmino Acids, Sulfurbranched-chain-amino-acid transaminaseCysteineCystineMethioninePhenylalanineTransaminasesTyrosine

Identifiers

PMID22332087
PMCPMC3226382
OpenAlexW1995187187

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.