ReviewAdvances in nutrition (Bethesda, Md.)2011
Nutritionally mediated programming of the developing immune system.
Review in Advances in nutrition (Bethesda, Md.), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03657836 (Evaluation of Effectiveness of the Sublimated Mare Milk Supplement in Protection of Gut Mucosal Lining During Antibiotic Treatment), which is not on this map. Cited by 96 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluation of Effectiveness of the Sublimated Mare Milk Supplement in Protection of Gut Mucosal Lining During Antibiotic Treatment
Who cites it
96 citing papers in PubMed, 3 syntheses or guidelines pooled it, 201 citations in OpenAlex.
- Sensitive periods to social adversity in immune and metabolic development: A systematic review.Psychoneuroendocrinology · 2025Pooled it
- Pooled it
- Plasticity of intestinal gene expression profile signatures reflected by nutritional interventions in piglets.BMC genomics · 2019Pooled it
- Immunogenicity of an oral rotavirus vaccine administered with prenatal nutritional support in Niger: A cluster randomized clinical trial.PLoS medicine · 2021Trial
- Maternal dietary diversity and dietary quality scores in relation to adverse birth outcomes in Tanzanian women.The American journal of clinical nutrition · 2020Trial
- Impact of nutritional supplementation during pregnancy on antibody responses to diphtheria-tetanus-pertussis vaccination in infants: A randomised trial in The Gambia.PLoS medicine · 2019Trial
- Trial
- Effects of Timing of Microbial Exposure on Microbiome Assembly and Amphibian Immune Development.Ecology and evolution · 2026Article
- Maternal Low-Fat and High-Fat Diet Decreases Survival and Alters Cytokine Signaling in Neonatal Mice With Staphylococcus epidermidis Sepsis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
- Active tuberculosis disease in pregnancy alters frequencies of B-cell subsets among exposed neonates in Uganda.BMC immunology · 2026Article
- Unravelling the effect of parity on immunoglobulins, cytokines and adipokines in human transitional milk and their association with infant infections during the first 6 months of life.International breastfeeding journal · 2025Article
- Antagonistic activity of butanamine 2,2-dinitro-N-methyl- synthesized by endosymbiotic Bacillus amyloliquefaciens VITAPRJS1 acquired from horse milk.International microbiology : the official journal of the Spanish Society for Microbiology · 2025Article
- Selective mortality during famine and plague events in medieval London.Scientific reports · 2025Article
- Sex-specific association of immunological markers in CS-delivered newborns with pre-pregnancy body mass index and gestational weight gain of mothers.Scientific reports · 2025Article
- The effect of late gestation injectable vitamin A and D supplementation on sow and piglet performance.Translational animal science · 2025Article
- Perinatal Exposure of Dams to a High Salt Diet Impaired Vascular Function and Elevated Biomarkers of Inflammation in the Offspring.Clinical Medicine Insights. Cardiology · 2025Article
- Dying of pestilence: Stature and mortality from the Black Death in 14th-century Kyrgyzstan.American journal of biological anthropology · 2024Article
- Postnatal supplementation with alarmins S100a8/a9 ameliorates malnutrition-induced neonate enteropathy in mice.Nature communications · 2024Article
- From Womb to World: Exploring the Immunological Connections between Mother and Child.ImmunoHorizons · 2024Review
- Maternal Adverse Childhood Experiences and Biological Aging During Pregnancy and in Newborns.JAMA network open · 2024Article
36 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A growing body of evidence highlights the importance of a mother's nutrition from preconception through lactation in programming the emerging organ systems and homeostatic pathways of her offspring. The developing immune system may be particularly vulnerable. Indeed, examples of nutrition-mediated immune programming can be found in the literature on intra-uterine growth retardation, maternal micronutrient deficiencies, and infant feeding. Current models of immune ontogeny depict a "layered" expansion of increasingly complex defenses, which may be permanently altered by maternal malnutrition. One programming mechanism involves activation of the maternal hypothalamic-pituitary-adrenal axis in response to nutritional stress. Fetal or neonatal exposure to elevated stress hormones is linked in animal studies to permanent changes in neuroendocrine-immune interactions, with diverse manifestations such as an attenuated inflammatory response or reduced resistance to tumor colonization. Maternal malnutrition may also have a direct influence, as evidenced by nutrient-driven epigenetic changes to developing T regulatory cells and subsequent risk of allergy or asthma. A 3rd programming pathway involves placental or breast milk transfer of maternal immune factors with immunomodulatory functions (e.g. cytokines). Maternal malnutrition can directly affect transfer mechanisms or influence the quality or quantity of transferred factors. The public health implications of nutrition-mediated immune programming are of particular importance in the developing world, where prevalent maternal undernutrition is coupled with persistent infectious challenges. However, early alterations to the immune system, resulting from either nutritional deficiencies or excesses, have broad relevance for immune-mediated diseases, such as asthma, and chronic inflammatory conditions like cardiovascular disease.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.