ReviewAdvances in nutrition (Bethesda, Md.)2011
Effects of ruminant trans fatty acids on cardiovascular disease and cancer: a comprehensive review of epidemiological, clinical, and mechanistic studies.
Review in Advances in nutrition (Bethesda, Md.), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
72 citing papers in PubMed, 2 syntheses or guidelines pooled it, 263 citations in OpenAlex.
- Intake of saturated and trans unsaturated fatty acids and risk of all cause mortality, cardiovascular disease, and type 2 diabetes: systematic review and meta-analysis of observational studies.BMJ (Clinical research ed.) · 2015Pooled it
- Association of foods enriched in conjugated linoleic acid (CLA) and CLA supplements with lipid profile in human studies: a systematic review and meta-analysis.Public health nutrition · 2015Pooled it
- Trans fatty acids in adipose tissue and risk of myocardial infarction: A case-cohort study.PloS one · 2018Trial
- Effect of oilseed type on milk fatty acid composition of individual cows, and also bulk tank milk fatty acid composition from commercial farms.Animal : an international journal of animal bioscience · 2017Trial
- Trial
- The effects of changing dairy intake on trans and saturated fatty acid levels- results from a randomized controlled study.Nutrition journal · 2014Trial
- Plasma phospholipid trans fatty acids and risk of heart failure.The American journal of clinical nutrition · 2013Trial
- Trans-vaccenic acid reduces HT-29 colorectal cancer cell viability and is associated with changes in apoptosis-, lipid metabolism-, and survival-related gene and candidate miRNA expression.Molecular biology reports · 2026Article
- Maternal trans-vaccenic acid shapes neonatal T cell development and early-life immune imprinting.Science (New York, N.Y.) · 2026Article
- Total Fat and Fatty Acid Content in Meals Served by Independent Takeaway Outlets Participating in the Healthier Catering Commitment Initiative in London, UK.International journal of environmental research and public health · 2025Article
- Differential effects of elevated cholesterol and fatty acids on endothelial function: Mechanisms contributing to atherosclerosis development.Bioinformation · 2025Article
- A Comparative Analysis of Butter, Ghee, and Margarine and Its Implications for Healthier Fat and Oil Group Choices: SWOT Analysis.Food science & nutrition · 2024Article
- Effects of beef fat enriched withThe British journal of nutrition · 2024Article
- Disability and costs of IHD attributable to the consumption of trans-fatty acids in Brazil.Public health nutrition · 2024Article
- Beef production and the beef evaluation system in Chile: description, characterization, and quality.Animal frontiers : the review magazine of animal agriculture · 2024Article
- Allele-specific effect of various dietary fatty acids and ETS1 transcription factor on SCD1 expression.Scientific reports · 2024Article
- Serum albumin levels and risk of atrial fibrillation: a Mendelian randomization study.Frontiers in cardiovascular medicine · 2024Article
- Trans-vaccenic acid reprograms CD8Nature · 2023Article
- Associations between dietary fatty acid patterns and cognitive function in the Hispanic Community Health Study/Study of Latinos.The British journal of nutrition · 2023Article
- C57bl/6 Mice Show Equivalent Taste Preferences toward Ruminant and Industrial Trans Fatty Acids.Nutrients · 2023Article
12 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 6 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There are 2 predominant sources of dietary trans fatty acids (TFA) in the food supply, those formed during the industrial partial hydrogenation of vegetable oils (iTFA) and those formed by biohydrogenation in ruminants (rTFA), including vaccenic acid (VA) and the naturally occurring isomer of conjugated linoleic acid, cis-9, trans-11 CLA (c9,t11-CLA). The objective of this review is to evaluate the evidence base from epidemiological and clinical studies to determine whether intake of rTFA isomers, specifically VA and c9,t11-CLA, differentially affects risk of cardiovascular disease (CVD) and cancer compared with iTFA. In addition, animal and cell culture studies are reviewed to explore potential pro- and antiatherogenic mechanisms of VA and c9,t11-CLA. Some epidemiological studies suggest that a positive association with coronary heart disease risk exists between only iTFA isomers and not rTFA isomers. Small clinical studies have been conducted to establish cause-and-effect relationships between these different sources of TFA and biomarkers or risk factors of CVD with inconclusive results. The lack of detection of treatment effects reported in some studies may be due to insufficient statistical power. Many studies have used doses of rTFA that are not realistically attainable via diet; thus, further clinical studies are warranted. Associations between iTFA intake and cancer have been inconsistent, and associations between rTFA intake and cancer have not been well studied. Clinical studies have not been conducted investigating the cause-and-effect relationship between iTFA and rTFA intake and risk for cancers. Further research is needed to determine the health effects of VA and c9,t11-CLA in humans.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.