ArticleHuman brain mapping2013
Resting state cortical electroencephalographic rhythms are related to gray matter volume in subjects with mild cognitive impairment and Alzheimer's disease.
Article in Human brain mapping, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 3 of them syntheses that pooled it.
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Who cites it
57 citing papers in PubMed, 3 syntheses or guidelines pooled it, 169 citations in OpenAlex.
- Exploring easily accessible neurophysiological biomarkers for predicting Alzheimer's disease progression: a systematic review.Alzheimer's research & therapy · 2024Pooled it
- Investigating Auditory Electrophysiological Measures of Participants with Mild Cognitive Impairment and Alzheimer's Disease: A Systematic Review and Meta-Analysis of Event-Related Potential Studies.Journal of Alzheimer's disease : JAD · 2021Pooled it
- Alpha Power and Functional Connectivity in Cognitive Decline: A Systematic Review and Meta-Analysis.Journal of Alzheimer's disease : JAD · 2020Pooled it
- ADAPT-2: A Randomized Clinical Trial to Reduce Intraoperative EEG Suppression in Older Surgical Patients Undergoing Major Noncardiac Surgery.Anesthesia and analgesia · 2020Trial
- Psilocybin-induced spiritual experiences and insightfulness are associated with synchronization of neuronal oscillations.Psychopharmacology · 2015Trial
- Neuroplastic effects of combined computerized physical and cognitive training in elderly individuals at risk for dementia: an eLORETA controlled study on resting states.Neural plasticity · 2015Trial
- Systematic Benchmarking of a Dry Electrode EEG Prototype Against Wet Electrode EEG Systems in Electrophysiological/Cognitive Scenarios.Biosensors · 2026Article
- Altered Neuromuscular Control and Beta-Band Cortical Compensation During Gait in Sarcopenia: An Exploratory Study.Bioengineering (Basel, Switzerland) · 2026Article
- Source-space EEG alpha activity reveals brain age gaps due to neurodegeneration and disparity.Communications biology · 2026Article
- Derivation of an intrinsic brain activity biomarker for the earliest prediction of cognitive decline.Scientific reports · 2026Article
- Exploring resting EEG correlates of age-related hearing difficulties.Frontiers in neuroscience · 2026Article
- Verbal learning in logopenic variant Primary Progressive Aphasia: An EEG investigation.Neurobiology of aging · 2026Article
- Recent Advancements of Transcranial Direct Current Stimulation and Machine Learning: Methods, Challenges, and Opportunities.Transactions on artificial intelligence · 2026Article
- Alpha rhythm and Alzheimer's disease: Has Hans Berger's dream come true?Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2025Article
- The role of quantitative EEG biomarkers in Alzheimer's disease and mild cognitive impairment: applications and insights.Frontiers in aging neuroscience · 2025Review
- Abnormal resting-state EEG neural oscillations and functional connectivity in mild cognitive impairment.Frontiers in aging neuroscience · 2025Article
- Resting-state EEG alterations and cognitive impairment in atrial fibrillation: insights into neural biomarkers and functional connectivity.Frontiers in neurology · 2025Article
- Parietal alpha and theta power predict cognitive training gains in middle-aged adults.Frontiers in aging neuroscience · 2025Article
- Quantitative electroencephalography (qEEG), apolipoprotein A-I (APOA-I), and apolipoprotein epsilon 4 (APOE ɛ4) alleles for the diagnosis of mild cognitive impairment and Alzheimer's disease.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Article
- Relationship between default mode network and resting-state electroencephalographic alpha rhythms in cognitively unimpaired seniors and patients with dementia due to Alzheimer's disease.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
Corrections and comments
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Authors and funding
27 authors at 13 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cortical gray matter volume and resting state cortical electroencephalographic rhythms are typically abnormal in subjects with amnesic mild cognitive impairment (MCI) and Alzheimer's disease (AD). Here we tested the hypothesis that in amnesic MCI and AD subjects, abnormalities of EEG rhythms are a functional reflection of cortical atrophy across the disease. Eyes-closed resting state EEG data were recorded in 57 healthy elderly (Nold), 102 amnesic MCI, and 108 AD patients. Cortical gray matter volume was indexed by magnetic resonance imaging recorded in the MCI and AD subjects according to Alzheimer's disease neuroimaging initiative project (http://www.adni-info.org/). EEG rhythms of interest were delta (2-4 Hz), theta (4-8 Hz), alpha1 (8-10.5 Hz), alpha2 (10.5-13 Hz), beta1 (13-20 Hz), beta2 (20-30 Hz), and gamma (30-40 Hz). These rhythms were indexed by LORETA. Compared with the Nold, the MCI showed a decrease in amplitude of alpha 1 sources. With respect to the Nold and MCI, the AD showed an amplitude increase of delta sources, along with a strong amplitude reduction of alpha 1 sources. In the MCI and AD subjects as a whole group, the lower the cortical gray matter volume, the higher the delta sources, the lower the alpha 1 sources. The better the score to cognitive tests the higher the gray matter volume, the lower the pathological delta sources, and the higher the alpha sources. These results suggest that in amnesic MCI and AD subjects, abnormalities of resting state cortical EEG rhythms are not epiphenomena but are strictly related to neurodegeneration (atrophy of cortical gray matter) and cognition.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.