ArticleHepatology (Baltimore, Md.)2012
HCV RNA levels in a multiethnic cohort of injection drug users: human genetic, viral and demographic associations.
Article in Hepatology (Baltimore, Md.), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00341484 (Genetic Susceptibility to Oncogenic Viruses), which is not on this map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Genetic Susceptibility to Oncogenic Viruses
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Interleukin gene polymorphisms and susceptibility to HIV-1 infection: a meta-analysis.Journal of genetics · 2018Pooled it
- Direct-Acting Antiviral Prophylaxis in Kidney Transplantation From Hepatitis C Virus-Infected Donors to Noninfected Recipients: An Open-Label Nonrandomized Trial.Annals of internal medicine · 2018Trial
- The IFN-λ4 Conundrum: When a Good Interferon Goes Bad.Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research · 2019Review
- Options for reducing HIV transmission related to the dead space in needles and syringes.Harm reduction journal · 2018Article
- IFN-λ4 Attenuates Antiviral Responses by Enhancing Negative Regulation of IFN Signaling.Journal of immunology (Baltimore, Md. : 1950) · 2017Article
- Article
- Influence of IFNL3 and HLA-DPB1 genotype on postpartum control of hepatitis C virus replication and T-cell recovery.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- The Prevalence of Hepatitis C Virus Core Amino Acid 70 Substitution and Genotypes of Polymorphisms Near the IFNL3 Gene in Iranian Patients With Chronic Hepatitis C.Hepatitis monthly · 2016Article
- Expression of Interferon Lambda 4 Is Associated with Reduced Proliferation and Increased Cell Death in Human Hepatic Cells.Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research · 2015Article
- Factors associated with hepatitis C virus RNA levels in early chronic infection: the InC3 study.Journal of viral hepatitis · 2015Article
- Article
- Interferon lambda 3 genotype predicts hepatitis C virus RNA levels in early acute infection among people who inject drugs: the InC(3) study.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2014Article
- Disease progression during advanced fibrosis: IL28B genotype or HCV RNA levels?Hepatology (Baltimore, Md.) · 2014Article
- The "hidden" epidemic: a snapshot of Moroccan intravenous drug users.Virology journal · 2014Article
- Association of the IFNL4-ΔG Allele With Impaired Spontaneous Clearance of Hepatitis C Virus.The Journal of infectious diseases · 2014Article
- A variant upstream of IFNL3 (IL28B) creating a new interferon gene IFNL4 is associated with impaired clearance of hepatitis C virus.Nature genetics · 2013Article
- Correlation of viral loads with HCV genotypes: higher levels of virus were revealed among blood donors infected with 6a strains.PloS one · 2012Article
- Association of genotypes with viral load and biochemical markers in HCV-infected Sindhi patients.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]Article
Corrections and comments
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Authors and funding
12 authors at 6 institutions in 2 countries.
Funding
Abstract
unlabelledIn patients with chronic hepatitis C, the hepatitis C virus (HCV) RNA level is an important predictor of treatment response. To explore the relationship of HCV RNA with viral and demographic factors, as well as IL28B genotype, we examined viral levels in an ethnically diverse group of injection drug users (IDUs). Between 1998 and 2000, the Urban Health Study (UHS) recruited IDUs from street settings in San Francisco Bay area neighborhoods. Participants who were positive by HCV enzyme immunoassay were tested for HCV viremia by a branched-chain DNA assay. HCV genotype was determined by sequencing the HCV nonstructural 5B protein region. For a subset of participants, IL28B rs12979860 genotype was determined by Taqman. Among 1,701 participants with HCV viremia, median age was 46 years and median duration of injection drug use was 26 years; 56.0% were African American and 34.0% were of European ancestry (non-Hispanic). Human immunodeficiency virus type 1 (HIV-1) prevalence was 13.9%. The overall median HCV RNA level was 6.45 log(10) copies/mL. In unadjusted analyses, higher levels were found with older age, male gender, African-American ancestry, hepatitis B virus infection, HIV-1 infection, and IL28B rs12979860-CC genotype; compared to participants infected with HCV genotype 1, HCV RNA was lower in participants with genotypes 3 or 4. In an adjusted analysis, age, gender, racial ancestry, HIV-1 infection, HCV genotype, and IL28B rs12979860 genotype were all independently associated with HCV RNA.
conclusionThe level of HCV viremia is influenced by a large number of demographic, viral, and human genetic factors.
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Registered trials
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