ArticleMolecular and cellular biology2012
MacroH2A1 regulates the balance between self-renewal and differentiation commitment in embryonic and adult stem cells.
Article in Molecular and cellular biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.
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Who cites it
60 citing papers in PubMed.
- MacroH2A-Mediated Gene Repression through Nucleosome Compaction and Remodeling Inhibition.bioRxiv : the preprint server for biology · 2026Article
- The Function of H2A Histone Variants and Their Roles in Diseases.Biomolecules · 2024Review
- Epigenetic control of cancer inflammation.Nature cell biology · 2023Article
- macroH2A2 antagonizes epigenetic programs of stemness in glioblastoma.Nature communications · 2023Article
- Article
- Evolution of a histone variant involved in compartmental regulation of NAD metabolism.Nature structural & molecular biology · 2021Article
- The Role of MacroH2A Histone Variants in Cancer.Cancers · 2021Review
- Epigenetic regulation of cancer stem cell formation and maintenance.International journal of cancer · 2021Review
- Low Replicative Stress Triggers Cell-Type Specific Inheritable Advanced Replication Timing.International journal of molecular sciences · 2021Article
- Article
- Histone variants in skeletal myogenesis.Epigenetics · 2021Review
- LSH mediates gene repression through macroH2A deposition.Nature communications · 2020Article
- Histone Variants: Guardians of Genome Integrity.Cells · 2020Review
- The roles of histone variants in fine-tuning chromatin organization and function.Nature reviews. Molecular cell biology · 2020Review
- The taming of PARP1 and its impact on NADMolecular metabolism · 2020Review
- Article
- A Role for the Biological Clock in Liver Cancer.Cancers · 2019Review
- Deficiency and haploinsufficiency of histone macroH2A1.1 in mice recapitulate hematopoietic defects of human myelodysplastic syndrome.Clinical epigenetics · 2019Article
- Zebrafish macroH2A variants have distinct embryo localization and function.Scientific reports · 2019Article
- Retargeting of macroH2A following mitosis to cytogenetic-scale heterochromatic domains.The Journal of cell biology · 2019Article
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Authors and funding
13 authors.
Funding
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Abstract
One of the most striking epigenetic alterations that occurs at the level of the nucleosome is the complete exchange of the canonical H2A histones for the macroH2A variant. Here, we provide insight into the poorly recognized function of macroH2A in transcriptional activation and demonstrate its relevance in embryonic and adult stem cells. Knockdown of macroH2A1 in mouse embryonic stem (mES) cells limited their capacity to differentiate but not their self-renewal. The loss of macroH2A1 interfered with the proper activation of differentiation genes, most of which are direct target genes of macroH2A. Additionally, macroH2A1-deficient mES cells displayed incomplete inactivation of pluripotency genes and formed defective embryoid bodies. In vivo, macroH2A1-deficient teratomas contained a massive expansion of malignant, undifferentiated carcinoma tissue. In the heterogeneous culture of primary human keratinocytes, macroH2A1 levels negatively correlated with the self-renewal capacity of the pluripotent compartment. Together these results establish macroH2A1 as a critical chromatin component that regulates the delicate balance between self-renewal and differentiation of embryonic and adult stem cells.
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