ArticlePlant physiology2012
Natural hypolignification is associated with extensive oligolignol accumulation in flax stems.
Article in Plant physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed.
- Combining Stable Isotope Labeling and Candidate Substrate-Product Pair Networks Reveals Lignan, Oligolignol, and Chicoric Acid Biosynthesis in Flax Seedlings (Plants (Basel, Switzerland) · 2025Article
- Genome-wide characterization and stress-responsive expression analysis of the cinnamoyl-CoA reductase gene family in soybean.Frontiers in plant science · 2025Article
- Comparative Analysis of G-Layers in Bast Fiber and Xylem Cell Walls in Flax Using Raman Spectroscopy.Biomolecules · 2023Article
- Identification of new potential molecular actors related to fiber quality in flax through Omics.Frontiers in plant science · 2023Article
- Metabolite Profiling of Paraquat TolerantAntioxidants (Basel, Switzerland) · 2022Article
- Article
- Review
- REPRISAL: mapping lignification dynamics using chemistry, data segmentation, and ratiometric analysis.Plant physiology · 2022Article
- Proteomics and Interspecies Interaction Analysis Revealed Abscisic Acid Signalling to Be the Primary Driver for Oil Palm's Response against Red Palm Weevil Infestation.Plants (Basel, Switzerland) · 2021Article
- Transcriptome and metabolome profiling provide insights into molecular mechanism of pseudostem elongation in banana.BMC plant biology · 2021Article
- Article
- The sugarcane ShMYB78 transcription factor activates suberin biosynthesis in Nicotiana benthamiana.Plant molecular biology · 2020Article
- Nontargeted Analysis Strategy for the Identification of Phenolic Compounds in Complex Technical Lignin Samples.ChemSusChem · 2020Article
- Article
- Targeted Metagenomics of Retting in Flax: The Beginning of the Quest to Harness the Secret Powers of the Microbiota.Frontiers in genetics · 2020Review
- Insights into Lignan Composition and Biosynthesis in Stinging Nettle (Molecules (Basel, Switzerland) · 2019Article
- Oxidative Transformations of Lignans.Molecules (Basel, Switzerland) · 2019Review
- Identification of lignin oligomers in Kraft lignin using ultra-high-performance liquid chromatography/high-resolution multiple-stage tandem mass spectrometry (UHPLC/HRMSAnalytical and bioanalytical chemistry · 2018Article
- The cell biology of secondary cell wall biosynthesis.Annals of botany · 2018Review
- A genome-wide analysis of the flax (Linum usitatissimum L.) dirigent protein family: from gene identification and evolution to differential regulation.Plant molecular biology · 2018Article
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Flax (Linum usitatissimum) stems contain cells showing contrasting cell wall structure: lignified in inner stem xylem tissue and hypolignified in outer stem bast fibers. We hypothesized that stem hypolignification should be associated with extensive phenolic accumulation and used metabolomics and transcriptomics to characterize these two tissues. (1)H nuclear magnetic resonance clearly distinguished inner and outer stem tissues and identified different primary and secondary metabolites, including coniferin and p-coumaryl alcohol glucoside. Ultrahigh-performance liquid chromatography-Fourier transform ion cyclotron resonance-mass spectrometry aromatic profiling (lignomics) identified 81 phenolic compounds, of which 65 were identified, to our knowledge, for the first time in flax and 11 for the first time in higher plants. Both aglycone forms and glycosides of monolignols, lignin oligomers, and (neo)lignans were identified in both inner and outer stem tissues, with a preponderance of glycosides in the hypolignified outer stem, indicating the existence of a complex monolignol metabolism. The presence of coniferin-containing secondary metabolites suggested that coniferyl alcohol, in addition to being used in lignin and (neo)lignan formation, was also utilized in a third, partially uncharacterized metabolic pathway. Hypolignification of bast fibers in outer stem tissues was correlated with the low transcript abundance of monolignol biosynthetic genes, laccase genes, and certain peroxidase genes, suggesting that flax hypolignification is transcriptionally regulated. Transcripts of the key lignan genes Pinoresinol-Lariciresinol Reductase and Phenylcoumaran Benzylic Ether Reductase were also highly abundant in flax inner stem tissues. Expression profiling allowed the identification of NAC (NAM, ATAF1/2, CUC2) and MYB transcription factors that are likely involved in regulating both monolignol production and polymerization as well as (neo)lignan production.
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