ArticleIntensive care medicine2012
Circulating endothelial progenitor cells inversely associate with organ dysfunction in sepsis.
Article in Intensive care medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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Who cites it
26 citing papers in PubMed, 47 citations in OpenAlex.
- Macrophages-derived high-mobility group box-1 protein induces endothelial progenitor cells pyroptosis.iScience · 2024Article
- The bone marrow endothelial progenitor cell response to septic infection.Frontiers in immunology · 2024Article
- Endothelial progenitor cells in the host defense response.Pharmacology & therapeutics · 2023Review
- Endothelial Progenitor Cell-Derived Extracellular Vesicles: Potential Therapeutic Application in Tissue Repair and Regeneration.International journal of molecular sciences · 2021Review
- High mobilization of CD133+/CD34+ cells expressing HIF-1α and SDF-1α in septic abdominal surgical patients.BMC anesthesiology · 2020Article
- Mobilization of endothelial progenitor cells in sepsis.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2020Review
- Interleukin-26 is overexpressed in human sepsis and contributes to inflammation, organ injury, and mortality in murine sepsis.Critical care (London, England) · 2019Article
- Circulating stem cells, HIF-1, and SDF-1 in septic abdominal surgical patients: randomized controlled study protocol.Trials · 2018Article
- VCAM-1 expression is upregulated by CD34+/CD133+-stem cells derived from septic patients.PloS one · 2018Article
- Neuromuscular electrical stimulation acutely mobilizes endothelial progenitor cells in critically ill patients with sepsis.Annals of intensive care · 2016Article
- Protective Role of Kallistatin in Vascular and Organ Injury.Hypertension (Dallas, Tex. : 1979) · 2016Review
- Detrimental cross-talk between sepsis and acute kidney injury: new pathogenic mechanisms, early biomarkers and targeted therapies.Critical care (London, England) · 2016Review
- Expanded endothelial progenitor cells mitigate lung injury in septic mice.Stem cell research & therapy · 2015Article
- Non-cultured dermal-derived mesenchymal cells attenuate sepsis induced by cecal ligation and puncture in mice.Scientific reports · 2015Article
- Resident Endothelial Cells and Endothelial Progenitor Cells Restore Endothelial Barrier Function After Inflammatory Lung Injury.Arteriosclerosis, thrombosis, and vascular biology · 2015Article
- Evaluation of endothelial damage in sepsis-related ARDS using circulating endothelial cells.Intensive care medicine · 2015Article
- Endothelial progenitor cells proliferated via MEK-dependent p42 MAPK signaling pathway.Molecular and cellular biochemistry · 2015Article
- Novel role of kallistatin in vascular repair by promoting mobility, viability, and function of endothelial progenitor cells.Journal of the American Heart Association · 2014Article
- Endothelial progenitor cells and a stromal cell-derived factor-1α analogue synergistically improve survival in sepsis.American journal of respiratory and critical care medicine · 2014Article
- Concise review: current status of stem cells and regenerative medicine in lung biology and diseases.Stem cells (Dayton, Ohio) · 2014Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
purposeEndothelial dysfunction is a primary contributor to sepsis-related organ dysfunction and death. In sepsis animal models, endothelial progenitor cells (EPC) have contributed to vascular repair. The role of endothelial progenitor cells as a biomarker for organ dysfunction is still unknown. We hypothesized that circulating numbers of endothelial progenitor cells would be associated with improved outcomes in sepsis.
methodsProspective, observational single-center cohort study in adult intensive care units at Grady Memorial Hospital, an affiliate of Emory University, from July 2007 through April 2009. Peripheral blood was obtained from 95 patients with sepsis, 37 intensive care unit controls, and 51 healthy controls, of whom only 86 patients with sepsis were used in the analysis because we were not able to obtain enough blood in 9 sepsis patients. Clinical data were obtained, and organ dysfunction was measured by Sepsis-Related Organ Failure Assessment (SOFA) score. Endothelial progenitor cells were assessed by a colony-forming unit (CFU) assay in which peripheral blood mononuclear cells were isolated using Ficoll density-gradient centrifugation and cultured in growth media.
resultsThe patients with sepsis had significantly lower mean endothelial progenitor cell colony counts compared with intensive care unit controls (p = 0.035) and healthy controls (p = 0.0005). There was no difference in colony counts between ICU controls and healthy controls (p = 0.81). In the sepsis patients, EPC CFU numbers inversely associated with SOFA score, adjusting for mortality (r (2) = 0.05, p = 0.04).
conclusionIncreased circulating endothelial progenitor cells inversely correlate with organ dysfunction in sepsis patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.