ArticleJournal of cell science2012
CoREST acts as a positive regulator of Notch signaling in the follicle cells of Drosophila melanogaster.
Article in Journal of cell science, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 32 citations in OpenAlex.
- Single-cell transcriptomics reveals stepwise transformation of epithelial cells into Non-Professional Phagocytes.PLoS genetics · 2025Article
- The CoREST complex regulates multiple histone modifications temporal-specifically in clock neurons.Open biology · 2024Article
- RCOR1 is targeted by miR-23b-3p to modulate growth, colony formation, migration, and invasion of prostate cancer cells.International journal of clinical and experimental pathology · 2024Article
- SPR-1/CoREST facilitates the maternal epigenetic reprogramming of the histone demethylase SPR-5/LSD1.Genetics · 2023Article
- Comprehensive analysis of REST corepressors (Frontiers in cell and developmental biology · 2023Article
- Distinct CoREST complexes act in a cell-type-specific manner.Nucleic acids research · 2019Article
- CoRest1 regulates neurogenesis in a stage-dependent manner.Developmental dynamics : an official publication of the American Association of Anatomists · 2019Article
- Downregulation of homeodomain protein Cut is essential forDevelopment (Cambridge, England) · 2019Article
- Oncogenic Notch Triggers Neoplastic Tumorigenesis in a Transition-Zone-like Tissue Microenvironment.Developmental cell · 2019Article
- Fizzy-Related dictates A cell cycle switch during organ repair and tissue growth responses in theeLife · 2018Article
- Article
- The histone deacetylase HDAC1 positively regulates Notch signaling duringBiology open · 2018Article
- Integration of Drosophila and Human Genetics to Understand Notch Signaling Related Diseases.Advances in experimental medicine and biology · 2018Review
- CoREST1 promotes tumor formation and tumor stroma interactions in a mouse model of breast cancer.PloS one · 2015Article
- The progenitor state is maintained by lysine-specific demethylase 1-mediated epigenetic plasticity during Drosophila follicle cell development.Genes & development · 2014Article
- E(y)1/TAF9 mediates the transcriptional output of Notch signaling in Drosophila.Journal of cell science · 2014Article
- Regulation of broad by the Notch pathway affects timing of follicle cell development.Developmental biology · 2014Article
- Differential properties of transcriptional complexes formed by the CoREST family.Molecular and cellular biology · 2014Article
- Induction of endocycles represses apoptosis independently of differentiation and predisposes cells to genome instability.Development (Cambridge, England) · 2014Article
- CAF-1 promotes Notch signaling through epigenetic control of target gene expression during Drosophila development.Development (Cambridge, England) · 2013Article
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
The Notch signaling pathway plays important roles in a variety of developmental events. The context-dependent activities of positive and negative modulators dramatically increase the diversity of cellular responses to Notch signaling. In a screen for mutations affecting the Drosophila melanogaster follicular epithelium, we isolated a mutation in CoREST that disrupts the Notch-dependent mitotic-to-endocycle switch of follicle cells at stage 6 of oogenesis. We show that Drosophila CoREST positively regulates Notch signaling, acting downstream of the proteolytic cleavage of Notch but upstream of Hindsight activity; the Hindsight gene is a Notch target that coordinates responses in the follicle cells. We show that CoREST genetically interacts with components of the Notch repressor complex, Hairless, C-terminal Binding Protein and Groucho. In addition, we demonstrate that levels of H3K27me3 and H4K16 acetylation are dramatically increased in CoREST mutant follicle cells. Our data indicate that CoREST acts as a positive modulator of the Notch pathway in the follicular epithelium as well as in wing tissue, and suggests a previously unidentified role for CoREST in the regulation of Notch signaling. Given its high degree of conservation among species, CoREST probably also functions as a regulator of Notch-dependent cellular events in other organisms.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.