Evidence map›Paper›PMID 22331336›Full record

Trial reportPediatrics2012

Hemodynamic effects of delayed cord clamping in premature infants.

Ross Sommers, Barbara S Stonestreet, William Oh, Abbot Laptook, Toby Debra Yanowitz, Christina Raker, Judith Mercer

Abstract readComparative StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Pediatrics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
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  7. Placental transfusion in preterm neonates of 30-33 weeks' gestation: a randomized controlled trial.Journal of perinatology : official journal of the California Perinatal Association · 2018
    Trial
  8. [Influence of delayed cord clamping on preterm infants with a gestational age of <32 weeks].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2016
    Trial
  9. Timing of umbilical cord clamping among infants born at 22 through 27 weeks' gestation.Journal of perinatology : official journal of the California Perinatal Association · 2016
    Trial
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  12. Trial
  13. Article
  14. Review
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  18. Monitoring and evaluation of hypotension in the extremely preterm.Frontiers in cardiovascular medicine · 2024
    Review
  19. Observational
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Ross SommersDepartment of Neonatology, Women & Infants Hospital of Rhode Island & Alpert Medical School of Brown University, Providence, RI 02905, USA. drsommers@gmail.com
Barbara S Stonestreet
William Oh
Abbot Laptook
Toby Debra Yanowitz
Christina Raker
Judith Mercer

Funding

PROTECTIVE EFFECTS OF DELAYED CORD CLAMPING IN VLBW INFANTSR01NR010015 · NINR · UNIVERSITY OF RHODE ISLAND · PI MERCER, JUDITH SMITH · 2008 to 2012
$1.9M
NINR NIH HHS 5R01NR010015NINR NIH HHS R01 NR010015
6 · The paper itself

Abstract

BACKGROUND AND

objectiveDelayed cord clamping (DCC) has been advocated during preterm delivery to improve hemodynamic stability during the early neonatal period. The hemodynamic effects of DCC in premature infants after birth have not been previously examined. Our objective was to compare the hemodynamic differences between premature infants randomized to either DCC or immediate cord clamping (ICC).

methodsThis prospective study was conducted on a subset of infants who were enrolled in a randomized controlled trial to evaluate the effects of DCC versus ICC. Entry criteria included gestational ages of 24(0) to 31(6) weeks. Twins and infants of mothers with substance abuse were excluded. Serial Doppler studies were performed at 6 ± 2, 24 ± 4, 48 ± 6, and 108 ± 12 hours of life. Measurements included superior vena cava blood flow, right ventricle output, middle cerebral artery blood flow velocity (BFV), superior mesenteric artery BFV, left ventricle shortening fraction, and presence of a persistent ductus arteriosus.

resultsTwenty-five infants were enrolled in the DCC group and 26 in the ICC group. Gestational age, birth weight, and male gender were similar. Admission laboratory and clinical events were also similar. DCC resulted in significantly higher superior vena cava blood flow over the study period, as well as greater right ventricle output and right ventricular stroke volumes at 48 hours. No differences were noted in middle cerebral artery BFV, mean superior mesenteric artery BFV, shortening fraction, or the incidence of a persistent ductus arteriosus.

conclusionsDCC in premature infants is associated with potentially beneficial hemodynamic changes over the first days of life.

Indexed as

Infant, PrematureUmbilical CordAnalysis of VarianceBlood Flow VelocityCerebral HemorrhageConstrictionDelivery, ObstetricDuctus Arteriosus, PatentFemaleFollow-Up StudiesHemodynamicsHumansInfant, NewbornInfant, Premature, DiseasesMaleOxygen Consumption

Identifiers

PMID22331336
PMCPMC3356138

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.