ArticleNeurorehabilitation and neural repair
Methods for functional assessment after C7 spinal cord hemisection in the rhesus monkey.
Article in Neurorehabilitation and neural repair. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 48 citations in OpenAlex.
- Emergence of functionally aberrant and subsequent reduction of neuromuscular connectivity and improved motor performance after cervical spinal cord injury in Rhesus.Frontiers in rehabilitation sciences · 2023Article
- Immune response following traumatic spinal cord injury: Pathophysiology and therapies.Frontiers in immunology · 2022Review
- How to generate graded spinal cord injuries in swine - tools and procedures.Disease models & mechanisms · 2021Article
- Longitudinal fMRI measures of cortical reactivation and hand use with and without training after sensory loss in primates.NeuroImage · 2021Article
- Acute spinal cord injury: Pathophysiology and pharmacological intervention (Review).Molecular medicine reports · 2021Review
- Restorative effects of human neural stem cell grafts on the primate spinal cord.Nature medicine · 2018Article
- Enhanced axonal transport: A novel form of "plasticity" after primate and rodent spinal cord injury.Experimental neurology · 2018Article
- Neuroprotective effect of local hypothermia in a computer-controlled compression model in minipig: Correlation of tissue sparing along the rostro-caudal axis with neurological outcome.Experimental and therapeutic medicine · 2018Article
- Functional Test Scales for Evaluating Cell-Based Therapies in Animal Models of Spinal Cord Injury.Stem cells international · 2017Review
- Evaluation of the neural function of nonhuman primates with spinal cord injury using an evoked potential-based scoring system.Scientific reports · 2016Article
- A Unilateral Cervical Spinal Cord Contusion Injury Model in Non-Human Primates (Macaca mulatta).Journal of neurotrauma · 2016Article
- Leveraging biomedical informatics for assessing plasticity and repair in primate spinal cord injury.Brain research · 2015Review
- Pronounced species divergence in corticospinal tract reorganization and functional recovery after lateralized spinal cord injury favors primates.Science translational medicine · 2015Article
- Development of a database for translational spinal cord injury research.Journal of neurotrauma · 2014Article
- The Irvine, Beatties, and Bresnahan (IBB) Forelimb Recovery Scale: An Assessment of Reliability and Validity.Frontiers in neurology · 2014Article
- The reactivation of somatosensory cortex and behavioral recovery after sensory loss in mature primates.Frontiers in systems neuroscience · 2014Review
- Role of Direct vs. Indirect Pathways from the Motor Cortex to Spinal Motoneurons in the Control of Hand Dexterity.Frontiers in neurology · 2013Review
- Animal models of neurologic disorders: a nonhuman primate model of spinal cord injury.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2012Review
- Syndromics: a bioinformatics approach for neurotrauma research.Translational stroke research · 2011Article
Corrections and comments
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Authors and funding
16 authors at 6 institutions in 2 countries.
Funding
Abstract
backgroundReliable outcome measures are essential for preclinical modeling of spinal cord injury (SCI) in primates. MEASURES: need to be sensitive to both increases and decreases in function in order to demonstrate potential positive or negative effects of therapeutics.
objectivesTo develop behavioral tests and analyses to assess recovery of function after SCI in the nonhuman primate.
methodsIn all, 24 male rhesus macaques were subjected to complete C7 lateral hemisection. The authors scored recovery of function in an open field and during hand tasks in a restraining chair. In addition, EMG analyses were performed in the open field, during hand tasks, and while animals walked on a treadmill. Both control and treated monkeys that received candidate therapeutics were included in this report to determine whether the behavioral assays were capable of detecting changes in function over a wide range of outcomes.
resultsThe behavioral assays are shown to be sensitive to detecting a wide range of motor functional outcomes after cervical hemisection in the nonhuman primate. Population curves on recovery of function were similar across the different tasks; in general, the population recovers to about 50% of baseline performance on measures of forelimb function.
conclusionsThe behavioral outcome measures that the authors developed in this preclinical nonhuman primate model of SCI can detect a broad range of motor recovery. A set of behavioral assays is an essential component of a model that will be used to test efficacies of translational candidate therapies for SCI.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.