ArticleAntimicrobial agents and chemotherapy2012
Efficacy of posaconazole in murine experimental sporotrichosis.
Article in Antimicrobial agents and chemotherapy, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 34 citations in OpenAlex.
- Osteoarticular Mycoses.Clinical microbiology reviews · 2022Review
- Current Models to Study theFrontiers in fungal biology · 2022Review
- Canine sporotrichosis: polyphasic taxonomy and antifungal susceptibility profiles of Sporothrix species in an endemic area in Brazil.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2021Article
- The threat of emerging and re-emerging pathogenic Sporothrix species.Mycopathologia · 2020Review
- Central Nervous System Infection with Other Endemic Mycoses: Rare Manifestation of Blastomycosis, Paracoccidioidomycosis, Talaromycosis, and Sporotrichosis.Journal of fungi (Basel, Switzerland) · 2019Review
- An atypical cause of sporotrichosis in a cat.Medical mycology case reports · 2019Article
- Methodologies forMicrobial cell (Graz, Austria) · 2018Review
- Multicenter, International Study of MIC/MEC Distributions for Definition of Epidemiological Cutoff Values for Sporothrix Species Identified by Molecular Methods.Antimicrobial agents and chemotherapy · 2017Article
- Cutaneous Disseminated and Extracutaneous Sporotrichosis: Current Status of a Complex Disease.Journal of fungi (Basel, Switzerland) · 2017Review
- Article
- Molecular Diagnosis of Pathogenic Sporothrix Species.PLoS neglected tropical diseases · 2015Article
- In Vitro and In Vivo Efficacy of Amphotericin B Combined with Posaconazole against Experimental Disseminated Sporotrichosis.Antimicrobial agents and chemotherapy · 2015Article
- Dimorphic fungal osteoarticular infections.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2014Review
- Genetic diversity and antifungal susceptibility profiles in causative agents of sporotrichosis.BMC infectious diseases · 2014Article
- Sporotrichosis: an overview and therapeutic options.Dermatology research and practice · 2014Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We developed a murine model of systemic sporotrichosis by using three strains of each of the two commonest species causing sporotrichosis, i.e., Sporothrix schenckii sensu stricto and Sporothrix brasiliensis, in order to evaluate the efficacy of posaconazole (PSC). The drug was administered at a dose of 2.5 or 5 mg/kg of body weight twice a day by gavage, and one group was treated with amphotericin B (AMB) as a control treatment. Posaconazole, especially at 5 mg/kg, showed good efficacy against all the strains tested, regardless of their MICs, as measured by prolonged survival, tissue burden reduction, and histopathology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.