ArticleJournal of experimental botany2012
Genetic analysis of metabolites in apple fruits indicates an mQTL hotspot for phenolic compounds on linkage group 16.
Article in Journal of experimental botany, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Evaluation of Total Phenols, Flavonoids, and Antioxidant Activity in the Peel and Flesh of Old Apple Cultivars.Foods (Basel, Switzerland) · 2026Article
- Unveiling the genetic blueprint of verbascoside biosynthesis inHorticulture research · 2026Article
- Article
- Spinach (Foods (Basel, Switzerland) · 2025Article
- Untargeted metabolomic genome-wide association study reveals genetic and biochemical insights into polyphenols of apple fruit.Horticulture research · 2025Article
- Integrative analysis of genome-wide association studies of polyphenols in apple fruits identifies the MdDof2.4Horticulture research · 2025Article
- Tracing the color: quantitative trait loci analysis reveals new insights into red-flesh pigmentation in apple (Horticulture research · 2024Article
- An Insight into Abiotic Stress and Influx Tolerance Mechanisms in Plants to Cope in Saline Environments.Biology · 2022Review
- As It Stands: The Palouse Wild Cider Apple Breeding Program.Plants (Basel, Switzerland) · 2022Article
- Research Progress and Trends in Metabolomics of Fruit Trees.Frontiers in plant science · 2022Review
- Germplasm Resources and Strategy for Genetic Breeding ofFrontiers in plant science · 2022Review
- Research Progress on Genetic Basis of Fruit Quality Traits in Apple (Frontiers in plant science · 2022Review
- QTL analysis of important agronomic traits and metabolites in foxtail millet (Frontiers in plant science · 2022Article
- Understanding Omics Driven Plant Improvement andFrontiers in genetics · 2021Review
- Genome-wide association studies in apple reveal loci of large effect controlling apple polyphenols.Horticulture research · 2019Article
- Multifaceted analyses disclose the role of fruit size and skin-russeting in the accumulation pattern of phenolic compounds in apple.PloS one · 2019Article
- Metabolite variation in the lettuce gene pool: towards healthier crop varieties and food.Metabolomics : Official journal of the Metabolomic Society · 2018Article
- Sweet taste in apple: the role of sorbitol, individual sugars, organic acids and volatile compounds.Scientific reports · 2017Article
- Antioxidant Phytochemicals in Fresh Produce: Exploitation of Genotype Variation and Advancements in Analytical Protocols.Frontiers in chemistry · 2017Review
- Comparative and parallel genome-wide association studies for metabolic and agronomic traits in cereals.Nature communications · 2016Article
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Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Apple (Malus×domestica Borkh) is among the main sources of phenolic compounds in the human diet. The genetic basis of the quantitative variations of these potentially beneficial phenolic compounds was investigated. A segregating F₁ population was used to map metabolite quantitative trait loci (mQTLs). Untargeted metabolic profiling of peel and flesh tissues of ripe fruits was performed using liquid chromatography-mass spectrometry (LC-MS), resulting in the detection of 418 metabolites in peel and 254 in flesh. In mQTL mapping using MetaNetwork, 669 significant mQTLs were detected: 488 in the peel and 181 in the flesh. Four linkage groups (LGs), LG1, LG8, LG13, and LG16, were found to contain mQTL hotspots, mainly regulating metabolites that belong to the phenylpropanoid pathway. The genetics of annotated metabolites was studied in more detail using MapQTL®. A number of quercetin conjugates had mQTLs on LG1 or LG13. The most important mQTL hotspot with the largest number of metabolites was detected on LG16: mQTLs for 33 peel-related and 17 flesh-related phenolic compounds. Structural genes involved in the phenylpropanoid biosynthetic pathway were located, using the apple genome sequence. The structural gene leucoanthocyanidin reductase (LAR1) was in the mQTL hotspot on LG16, as were seven transcription factor genes. The authors believe that this is the first time that a QTL analysis was performed on such a high number of metabolites in an outbreeding plant species.
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