ArticleJournal of the American Association for Laboratory Animal Science : JAALAS2011
Effects of early atipamezole reversal of medetomidine-ketamine anesthesia in mice.
Article in Journal of the American Association for Laboratory Animal Science : JAALAS, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 31 citations in OpenAlex.
- Pleiotropic prodrugs for both symptomatic and disease-modifying treatment of Alzheimer's disease.Acta pharmaceutica Sinica. B · 2025Article
- Responding to medetomidine: clinical and public health needs.Lancet regional health. Americas · 2025Article
- Xylazine abuse, the growing risk: A review of its effects, upsurge use and associated fatalities in the USA and Puerto Rico.Journal of forensic and legal medicine · 2024Review
- Evaluation of general anesthesia protocols for a highly controlled cardiac ischemia-reperfusion model in mice.PloS one · 2024Article
- Recommended doses of medetomidine-midazolam-butorphanol with atipamezole for preventing hypothermia in mice.The Journal of veterinary medical science · 2022Article
- Alfaxalone-Xylazine Anesthesia in Laboratory Mice (Journal of the American Association for Laboratory Animal Science : JAALAS · 2019Article
- Comparison of Atipamezole with Yohimbine for Antagonism of Xylazine in Mice Anesthetized with Ketamine and Xylazine.Journal of the American Association for Laboratory Animal Science : JAALAS · 2017Article
- Anesthetic effects and body weight changes associated with ketamine-xylazine-lidocaine administered to CD-1 mice.PloS one · 2017Article
- Procoagulant and immunogenic properties of melanoma exosomes, microvesicles and apoptotic vesicles.Oncotarget · 2016Article
- Article
- Comparison of the effects of ketamine and fentanyl-midazolam-medetomidine for sedation of rhesus macaques (Macaca mulatta).BMC veterinary research · 2016Article
- Effects of an anesthetic mixture of medetomidine, midazolam, and butorphanol in rats-strain difference and antagonism by atipamezole.Experimental animals · 2016Article
- Anesthetic effects of a three-drugs mixture--comparison of administrative routes and antagonistic effects of atipamezole in mice.Experimental animals · 2015Article
- Atipamezole reverses ketamine-dexmedetomidine anesthesia without altering the antinociceptive effects of butorphanol and buprenorphine in female C57BL/6J mice.Journal of the American Association for Laboratory Animal Science : JAALAS · 2014Article
- Effects of isoflurane, ketamine-xylazine and a combination of medetomidine, midazolam and fentanyl on physiological variables continuously measured by telemetry in Wistar rats.BMC veterinary research · 2014Article
- Article
- Effects of some anesthetic agents on skin microcirculation evaluated by laser Doppler perfusion imaging in mice.BMC veterinary research · 2013Article
- Comparison of ketamine-xylazine and ketamine-dexmedetomidine anesthesia and intraperitoneal tolerance in rats.Journal of the American Association for Laboratory Animal Science : JAALAS · 2013Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rodents are often anesthetized by using ketamine and medetomidine, with reversal by atipamezole. Methods vary for times of administration of the atipamezole, and literature is lacking regarding appropriate reversal time. We investigated the recovery of mice reversed with atipamezole 10 min (early) or 40 min (late) after induction of anesthesia. Time to regain pinch-reflex or righting reflex did not differ between the 2 reversal points, but time to walking was significantly greater in mice that underwent early reversal with atipamezole. This delay was not mitigated by administration of atropine as part of the anesthetic regimen. Inclusion of acetylpromazine in the anesthetic regimen shortened the time needed to reach a surgical plane of anesthesia but also prolonged recovery times as determined by righting reflex and time to walking.
Indexed as
Identifiers
22330787PMC3228931W70081788What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.