ArticleJournal of the American Association for Laboratory Animal Science : JAALAS2011
Behavioral and activity assessment of laboratory mice (Mus musculus) after tail biopsy under isoflurane anesthesia.
Article in Journal of the American Association for Laboratory Animal Science : JAALAS, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 18 citations in OpenAlex.
- Evaluation of common anesthetic and analgesic techniques for tail biopsy in mice.Journal of the American Association for Laboratory Animal Science : JAALAS · 2012Trial
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- PEG-modified gadolinium nanoparticles as contrast agents for in vivo micro-CT.Scientific reports · 2021Article
- CREB deletion increases resilience to stress and downregulates inflammatory gene expression in the hippocampus.Brain, behavior, and immunity · 2019Article
- Comparing Phlebotomy by Tail Tip Amputation, Facial Vein Puncture, and Tail Vein Incision in C57BL/6 Mice by Using Physiologic and Behavioral Metrics of Pain and Distress.Journal of the American Association for Laboratory Animal Science : JAALAS · 2017Article
- Effects of Topical Anesthetics on Behavior, Plasma Corticosterone, and Blood Glucose Levels after Tail Biopsy of C57BL/6NHSD Mice (Mus musculus).Journal of the American Association for Laboratory Animal Science : JAALAS · 2016Article
- Adverse effects of vapocoolant and topical anesthesia for tail biopsy of preweanling mice.Journal of the American Association for Laboratory Animal Science : JAALAS · 2015Article
- Efficacy and safety of 5 anesthetics in adult zebrafish (Danio rerio).Journal of the American Association for Laboratory Animal Science : JAALAS · 2014Article
- Developmental and behavioral effects of toe clipping on neonatal and preweanling mice with and without vapocoolant anesthesia.Journal of the American Association for Laboratory Animal Science : JAALAS · 2014Article
- Local cryoanalgesia is effective for tail-tip biopsy in mice.Journal of the American Association for Laboratory Animal Science : JAALAS · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Contemporary laboratory animal guidance suggests that tail biopsy of laboratory mice can be performed before 21 d of age without anesthesia, whereas older mice must receive anesthesia before biopsy. Our objective was to determine whether administration of isoflurane anesthesia before tail biopsy produced a measurable effect on the behavior of mice (n = 196). We evaluated C57BL/6 and BALB/c mice at 21 to 24 (weaning), 28 to 31 (delayed weaning), and 42 to 45 (adult) d of age. Mice were observed at the time of biopsy and then twice within the first hour after a sham or tail biopsy. Anxiety-like responses were assessed by using an elevated plus-maze. Activity was evaluated remotely for 120 min. Isoflurane did not diminish acute responses to tail biopsy in mice 31 d or younger compared with sham-biopsied animals but had a significant effect in C57BL/6 biopsied adult mice. In addition, mice of all ages and strains that received anesthesia, regardless of biopsy, spent more time in the enclosed maze arms and had decreased activity up to 5 h after isoflurane exposure. Although tail biopsy should be performed in young mice to avoid transection of distal mature vertebrae, our experimental paradigm indicates that isoflurane anesthesia does not appreciably enhance wellbeing over that of mice biopsied without anesthesia at weaning ages. The influence of inhaled isoflurane was demonstrable and indicated that acute and prolonged alterations in anxiety and activity must be considered when interpreting the impact of anesthesia on tail biopsy across various ages and strains of laboratory mice.
Indexed as
Identifiers
22330716PMC3189673W96901059What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.