ArticleJournal of the American Association for Laboratory Animal Science : JAALAS2011
Administration of substances to laboratory animals: routes of administration and factors to consider.
Article in Journal of the American Association for Laboratory Animal Science : JAALAS, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 503 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
503 citing papers in PubMed, 4 syntheses or guidelines pooled it.
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- A comprehensive review of antimalarial medicinal plants used by Tanzanians.Pharmaceutical biology · 2024Pooled it
- Substance use and spine density: a systematic review and meta-analysis of preclinical studies.Molecular psychiatry · 2024Pooled it
- The gut microbiome-bile acid-FXR interplay: a pivotal axis in metabolic and gastrointestinal diseases.Gut microbes · 2026Review
- Pharmacokinetics and Tissue Distribution of Enrofloxacin and Its Metabolite Ciprofloxacin After a Single Intraperitoneal Administration in Black Rockfish (Animals : an open access journal from MDPI · 2026Article
- Development and Optimization of Sorafenib Nanosuspension By High-pressure Homogenization for Improved Oral Bioavailability.Pharmaceutical research · 2026Article
- Non-Proliferative Immune Restoration byJournal of microbiology and biotechnology · 2026Article
- Endogenous Expression of an RNA-Hydrolyzing Minibody Enhances the Therapeutic Effects Against Influenza a Virus Compared to Therapeutically Intranasal Administration.International journal of molecular sciences · 2026Article
- Pharmacokinetics and Efficacy of a Cyanide-Neutralizing [MoJournal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2026Article
- Pharmacokinetics and Brain Distribution of a Purine-Derived Neuroprotective Agent after Intranasal Administration in Neonatal Rats with Hypoxic-Ischemic Brain Injury.Pharmaceutical research · 2026Article
- Antioxidant Potential of Schistocerca gregaria (Orthoptera: Acrididae) Extract: HPLC Analysis, Molecular Docking, and Bioassays.Chemistry & biodiversity · 2026Article
- Pterostilbene Combating Cyclophosphamide-Induced Central Neuro-Inflammation in Rats: Effect on GFAP, PPAR- γ, NLRP3, COX-2 and Nrf2/HO-1 Pathway.Biomedicines · 2026Article
- In-dwelling microfluidic device for precise and reliable intranasal drug delivery during freely moving behavior.Lab animal · 2026Article
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- Morin Attenuates Hyperglycemia and Metabolic Dysregulation in Ovariectomized Diabetic Mouse Model.Medical sciences (Basel, Switzerland) · 2026Article
- Gastroprotective Activity of Myrtenol Derivatives Obtained by Biocatalytic Esterification and Photooxidation.Archiv der Pharmazie · 2026Article
- Feasibility and optimal imaging time window for intraperitoneal versus intravenous injection of a macrocyclic gadolinium-based contrast agent in mice.The Journal of international medical research · 2026Article
- Moving beyond oral gavage: micropipette-guided drug administration (MDA) as a 3R refinement for voluntary oral drug delivery in rodents.Lab animal · 2026Article
443 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Administration of substances to laboratory animals requires careful consideration and planning to optimize delivery of the agent to the animal while minimizing potential adverse experiences from the procedure. For all species, many different routes are available for administration of substances. The research team and IACUC members should be aware of reasons for selecting specific routes and of training and competency necessary for personnel to use these routes effectively. Once a route is selected, issues such as volume of administration, site of delivery, pH of the substance, and other factors must be considered to refine the technique. Inadequate training or inattention to detail during this aspect of a study may result in unintentional adverse effects on experimental animals and confounded results.
Indexed as
Identifiers
22330705PMC3189662What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.