ArticleComparative medicine2012
A rat model of diabetic wound infection for the evaluation of topical antimicrobial therapies.
Article in Comparative medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 70 citations in OpenAlex.
- Therapeutic efficacy and dermal safety of topical clove essential oil spray against bacterial, yeast, and fungal skin infections in rat models: A pilot non-inferiority study.Veterinary world · 2026Article
- Real-time detection and monitoring of bacteria in diabetic wounds using bacterial fluorescence.Frontiers in microbiology · 2026Article
- Alginate-based hydrogels loaded with human β-defensin-2 promote healing of MRSA-infected wounds in a diabetic model: a preclinical proof-of-concept study.Clinical and experimental medicine · 2025Article
- Phytofabricated Farsetia aegyptia-derived silver nanoparticles mediate antibacterial and wound-healing activities in diabetic foot infection rat model.Inflammopharmacology · 2025Article
- Low-Irradiance Antimicrobial Blue Light-Bathing Therapy for Wound Infection Control.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- The rat as an animal model in chronic wound research: An update.Life sciences · 2024Review
- Standardized Pre-clinical Surgical Animal Model Protocol to Investigate the Cellular and Molecular Mechanisms of Ischemic Flap Healing.Biological procedures online · 2024Article
- Electrospun Scaffolds as Antimicrobial Herbal Extract Delivery Vehicles for Wound Healing.Journal of functional biomaterials · 2023Article
- Development ofMolecular pharmaceutics · 2023Article
- Efficacy of Polydeoxyribonucleotide in Promoting the Healing of Diabetic Wounds in a Murine Model of Streptozotocin-Induced Diabetes: A Pilot Experiment.International journal of molecular sciences · 2023Article
- Review
- Accelerating the excisional wound closure by using the patterned microstructural nanofibrous mats/gentamicin-loaded hydrogel composite scaffold.Materials today. Bio · 2022Article
- Responsive and self-healing structural color supramolecular hydrogel patch for diabetic wound treatment.Bioactive materials · 2022Article
- Chitosan-Based Microparticle EncapsulatedTurkish journal of pharmaceutical sciences · 2022Article
- The Healing Capability of Clove Flower Extract (CFE) in Streptozotocin-Induced (STZ-Induced) Diabetic Rat Wounds Infected with Multidrug Resistant Bacteria.Molecules (Basel, Switzerland) · 2022Article
- Role of Animal Models to Advance Research of Bacterial Osteomyelitis.Frontiers in veterinary science · 2022Review
- Tang-Ping-San Decoction Remodel Intestinal Flora and Barrier to Ameliorate Type 2 Diabetes Mellitus in Rodent Model.Diabetes, metabolic syndrome and obesity : targets and therapy · 2022Article
- Acidified Nitrite Accelerates Wound Healing in Type 2 Diabetic Male Rats: A Histological and Stereological Evaluation.Molecules (Basel, Switzerland) · 2021Article
- Metabolomic profiling to reveal the therapeutic potency ofRSC advances · 2021Article
- Nanotechnology-Based Medical Devices for the Treatment of Chronic Skin Lesions: From Research to the Clinic.Pharmaceutics · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diabetes mellitus is an epidemic multisystemic chronic disease that frequently is complicated by complex wound infections. Innovative topical antimicrobial therapy agents are potentially useful for multimodal treatment of these infections. However, an appropriately standardized in vivo model is currently not available to facilitate the screening of these emerging products and their effect on wound healing. To develop such a model, we analyzed, tested, and modified published models of wound healing. We optimized various aspects of the model, including animal species, diabetes induction method, hair removal technique, splint and dressing methods, the control of unintentional bacterial infection, sampling methods for the evaluation of bacterial burden, and aspects of the microscopic and macroscopic assessment of wound healing, all while taking into consideration animal welfare and the '3Rs' principle. We thus developed a new wound infection model in rats that is optimized for testing topical antimicrobial therapy agents. This model accurately reproduces the pathophysiology of infected diabetic wound healing and includes the current standard treatment (that is, debridement). The numerous benefits of this model include the ready availability of necessary materials, simple techniques, high reproducibility, and practicality for experiments with large sample sizes. Furthermore, given its similarities to infected-wound healing and treatment in humans, our new model can serve as a valid alternative for applied research.
Indexed as
Identifiers
22330650PMC3276391W1597754227What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.