ArticleBMC evolutionary biology2012
Antagonistic experimental coevolution with a parasite increases host recombination frequency.
Article in BMC evolutionary biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 47 citations in OpenAlex.
- A high-resolution crossover landscape in Drosophila santomea reveals rapid and concerted evolution of multiple properties of crossing over control.PLoS genetics · 2025Article
- Evolutionary repeatability of emergent properties of ecological communities.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Review
- Article
- Variation in fine-scale recombination rate in temperature-evolved Drosophila melanogaster populations in response to selection.G3 (Bethesda, Md.) · 2022Article
- Microbial protection favors parasite tolerance and alters host-parasite coevolutionary dynamics.Current biology : CB · 2022Article
- Article
- Population size impacts host-pathogen coevolution.Proceedings. Biological sciences · 2021Article
- Selection for Plastic, Pathogen-Inducible Recombination in a Red Queen Model with Diploid Antagonists.Pathogens (Basel, Switzerland) · 2021Article
- Article
- Beetles as Model Organisms in Physiological, Biomedical and Environmental Studies - A Review.Frontiers in physiology · 2019Review
- Article
- The effect of parasite infection on the recombination rate of the mosquito Aedes aegypti.PloS one · 2018Article
- Variation in recombination frequency and distribution across eukaryotes: patterns and processes.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Review
- Experimental Evolution as an Underutilized Tool for Studying Beneficial Animal-Microbe Interactions.Frontiers in microbiology · 2016Review
- Genetic architecture of resistance in Daphnia hosts against two species of host-specific parasites.Heredity · 2015Article
- Bacteria-phage coevolution as a driver of ecological and evolutionary processes in microbial communities.FEMS microbiology reviews · 2014Review
- The ecology of sexual reproduction.Journal of evolutionary biology · 2014Review
- Variation in host resistance could limit the spread of more broadly virulent pathogens.Virulence · 2013Article
- Temporal dynamics of outcrossing and host mortality rates in host-pathogen experimental coevolution.Evolution; international journal of organic evolution · 2013Article
- Host resistance influences patterns of experimental viral adaptation and virulence evolution.Virulence · 2013Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOne of the big remaining challenges in evolutionary biology is to understand the evolution and maintenance of meiotic recombination. As recombination breaks down successful genotypes, it should be selected for only under very limited conditions. Yet, recombination is very common and phylogenetically widespread. The Red Queen Hypothesis is one of the most prominent hypotheses for the adaptive value of recombination and sexual reproduction. The Red Queen Hypothesis predicts an advantage of recombination for hosts that are coevolving with their parasites. We tested predictions of the hypothesis with experimental coevolution using the red flour beetle, Tribolium castaneum, and its microsporidian parasite, Nosema whitei.
resultsBy measuring recombination directly in the individuals under selection, we found that recombination in the host population was increased after 11 generations of coevolution. Detailed insights into genotypic and phenotypic changes occurring during the coevolution experiment furthermore helped us to reconstruct the coevolutionary dynamics that were associated with this increase in recombination frequency. As coevolved lines maintained higher genetic diversity than control lines, and because there was no evidence for heterozygote advantage or for a plastic response of recombination to infection, the observed increase in recombination most likely represented an adaptive host response under Red Queen dynamics.
conclusionsThis study provides direct, experimental evidence for an increase in recombination frequency under host-parasite coevolution in an obligatory outcrossing species. Combined with earlier results, the Red Queen process is the most likely explanation for this observation.
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