ArticleMolecules (Basel, Switzerland)2012
Chemical and biological analyses of the essential oils and main constituents of Piper species.
Article in Molecules (Basel, Switzerland), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.
- Effect of essential oils onParasitology · 2020Pooled it
- In Vitro Evaluation of Antileishmanial Activity of Commiphora myrrha Essential Oil Nanoliposome.Veterinary medicine and science · 2026Article
- Wild Pepper (Molecules (Basel, Switzerland) · 2024Article
- Volatile Components, Antioxidant and Phytotoxic Activity of the Essential Oil ofMolecules (Basel, Switzerland) · 2023Article
- Chemistry and Bioactivity ofMolecules (Basel, Switzerland) · 2023Article
- In Vitro Activity of Essential Oils fromMetabolites · 2023Article
- Anti-proliferative Activity ofCombinatorial chemistry & high throughput screening · 2023Article
- Essential Oil of the Plants Growing in the Brazilian Amazon: Chemical Composition, Antioxidants, and Biological Applications.Molecules (Basel, Switzerland) · 2022Review
- A Potential New Source of Therapeutic Agents for the Treatment of Mucocutaneous Leishmaniasis: The Essential Oil ofMolecules (Basel, Switzerland) · 2022Article
- Machine Learning Analysis of Essential Oils from Cuban Plants: Potential Activity against Protozoa Parasites.Molecules (Basel, Switzerland) · 2022Article
- Potential of Piper spp. as a source of new compounds for the leishmaniases treatment.Parasitology research · 2021Review
- Essential Oil fromMolecules (Basel, Switzerland) · 2020Article
- Article
- Review
- In-Vitro Evaluation of 52 Commercially-Available Essential Oils AgainstMolecules (Basel, Switzerland) · 2019Article
- Development of Nanoemulsions to Enhance the Antileishmanial Activity ofBioMed research international · 2018Article
- Essential Oils from Neotropical Piper Species and Their Biological Activities.International journal of molecular sciences · 2017Review
- In Vitro antileishmania activity of sesquiterpene-rich essential oils from Nectandra species.Pharmaceutical biology · 2017Article
- Evaluation of Chemical Composition and Antileishmanial and Antituberculosis Activities of Essential Oils of Piper Species.Molecules (Basel, Switzerland) · 2016Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The essential oils obtained from leaves of Piper duckei and Piper demeraranum by hydrodistillation were analyzed by gas chromatography-mass spectrometry. The main constituents found in P. demeraranum oil were limonene (19.3%) and β-elemene (33.1%) and in P. duckei oil the major components found were germacrene D (14.7%) and trans-caryophyllene (27.1%). P. demeraranum and P. duckei oils exhibited biological activity, with IC(50) values between 15 to 76 μg mL(-1) against two Leishmania species, P. duckei oil being the most active. The cytotoxicity of the essential oils on mice peritoneal macrophage cells was insignificant, compared with the toxicity of pentamidine. The main mono- and sesquiterpene, limonene (IC(50) = 278 μM) and caryophyllene (IC(50) = 96 μM), were tested against the strains of Leishmania amazonensis, and the IC(50) values of these compounds were lower than those found for the essential oils of the Piper species. The HET-CAM test was used to evaluate the irritation potential of these oils as topical products, showing that these oils can be used as auxiliary medication in cases of cutaneous leishmaniasis, with less side effects and lower costs.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.