ArticleNeural systems & circuits2011
Functional connectivity in a rhythmic inhibitory circuit using Granger causality.
Article in Neural systems & circuits, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Sensory and palatability coding of taste stimuli in cortex involves dynamic and asymmetric cortico-amygdalar interactions.Journal of neurophysiology · 2026Article
- Increased cortical plasticity leads to memory interference and enhanced hippocampal-cortical interactions.eLife · 2023Article
- Stimulus-specific plasticity in human visual gamma-band activity and functional connectivity.eLife · 2021Article
- Estimating Transfer Entropy in Continuous Time Between Neural Spike Trains or Other Event-Based Data.PLoS computational biology · 2021Article
- Article
- Dynamic core-periphery structure of information sharing networks in entorhinal cortex and hippocampus.Network neuroscience (Cambridge, Mass.) · 2020Article
- A study of problems encountered in Granger causality analysis from a neuroscience perspective.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Analysis of complex neural circuits with nonlinear multidimensional hidden state models.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Structure, Function, and Propagation of Information across Living Two, Four, and Eight Node Degree Topologies.Frontiers in bioengineering and biotechnology · 2016Article
- Feed-Forward Propagation of Temporal and Rate Information between Cortical Populations during Coherent Activation in Engineered In Vitro Networks.Frontiers in neural circuits · 2016Article
- Efficient "Shotgun" Inference of Neural Connectivity from Highly Sub-sampled Activity Data.PLoS computational biology · 2015Article
- Natural grouping of neural responses reveals spatially segregated clusters in prearcuate cortex.Neuron · 2015Article
- Neural Connectivity in Epilepsy as Measured by Granger Causality.Frontiers in human neuroscience · 2015Review
- An in vitro method to manipulate the direction and functional strength between neural populations.Frontiers in neural circuits · 2015Review
- Article
- Granger causality network reconstruction of conductance-based integrate-and-fire neuronal systems.PloS one · 2014Article
- Multiplex networks of cortical and hippocampal neurons revealed at different timescales.PloS one · 2014Article
- Functional connectivity among spikes in low dimensional space during working memory task in rat.PloS one · 2014Article
- Successful reconstruction of a physiological circuit with known connectivity from spiking activity alone.PLoS computational biology · 2013Article
- Dynamic effective connectivity of inter-areal brain circuits.PLoS computational biology · 2012Article
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Authors and funding
3 authors.
Funding
Abstract
backgroundUnderstanding circuit function would be greatly facilitated by methods that allow the simultaneous estimation of the functional strengths of all of the synapses in the network during ongoing network activity. Towards that end, we used Granger causality analysis on electrical recordings from the pyloric network of the crab Cancer borealis, a small rhythmic circuit with known connectivity, and known neuronal intrinsic properties.
resultsGranger causality analysis reported a causal relationship where there is no anatomical correlate because of the strong oscillatory behavior of the pyloric circuit. Additionally, we failed to find a direct relationship between synaptic strength and Granger causality in a set of pyloric circuit models.
conclusionsWe conclude that the lack of a relationship between synaptic strength and functional connectivity occurs because Granger causality essentially collapses the direct contribution of the synapse with the intrinsic properties of the postsynaptic neuron. We suggest that the richness of the dynamical properties of most biological neurons complicates the simple interpretation of the results of functional connectivity analyses using Granger causality.
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