ArticleNeural systems & circuits2011
Dynamic development of the first synapse impinging on adult-born neurons in the olfactory bulb circuit.
Article in Neural systems & circuits, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 24 citations in OpenAlex.
- Timing Matters: Lessons From Perinatal Neurogenesis in the Olfactory Bulb.The Journal of comparative neurology · 2025Article
- Signaling mechanisms underlying activity-dependent integration of adult-born neurons in the mouse olfactory bulb.Genesis (New York, N.Y. : 2000) · 2024Review
- A Pool of Postnatally Generated Interneurons Persists in an Immature Stage in the Olfactory Bulb.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Direct Recording of Dendrodendritic Excitation in the Olfactory Bulb: Divergent Properties of Local and External Glutamatergic Inputs Govern Synaptic Integration in Granule Cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Neuronal Circuitry Mechanisms Regulating Adult Mammalian Neurogenesis.Cold Spring Harbor perspectives in biology · 2016Review
- Adult neurogenesis is necessary to refine and maintain circuit specificity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Olfactory learning promotes input-specific synaptic plasticity in adult-born neurons.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Pathological α-synuclein impairs adult-born granule cell development and functional integration in the olfactory bulb.Nature communications · 2014Article
- Reorganization of neuronal circuits of the central olfactory system during postprandial sleep.Frontiers in neural circuits · 2013Review
- Early formation of GABAergic synapses governs the development of adult-born neurons in the olfactory bulb.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The olfactory bulb (OB) receives and integrates newborn interneurons throughout life. This process is important for the proper functioning of the OB circuit and consequently, for the sense of smell. Although we know how these new interneurons are produced, the way in which they integrate into the pre-existing ongoing circuits remains poorly documented. Bearing in mind that glutamatergic inputs onto local OB interneurons are crucial for adjusting the level of bulbar inhibition, it is important to characterize when and how these inputs from excitatory synapses develop on newborn OB interneurons. We studied early synaptic events that lead to the formation and maturation of the first glutamatergic synapses on adult-born granule cells (GCs), the most abundant subtype of OB interneuron. Patch-clamp recordings and electron microscopy (EM) analysis were performed on adult-born interneurons shortly after their arrival in the adult OB circuits. We found that both the ratio of N-methyl-D-aspartate receptor (NMDAR) to α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR), and the number of functional release sites at proximal inputs reached a maximum during the critical period for the sensory-dependent survival of newborn cells, well before the completion of dendritic arborization. EM analysis showed an accompanying change in postsynaptic density shape during the same period of time. Interestingly, the latter morphological changes disappeared in more mature newly-formed neurons, when the NMDAR to AMPAR ratio had decreased and functional presynaptic terminals expressed only single release sites. Together, these findings show that the first glutamatergic inputs to adult-generated OB interneurons undergo a unique sequence of maturation stages.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.