ReviewThe journal of spinal cord medicine2012
Osteoporosis in paediatric patients with spina bifida.
Review in The journal of spinal cord medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed.
- Neuromuscular training based on whole body vibration in children with spina bifida: a retrospective analysis of a new physiotherapy treatment program.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2015Trial
- Understanding Orthopaedic and Health-related Quality of Life Outcomes in Patients With Myelomeningocele Functional Classification 1 Spina Bifida in Relationship to Supportive Standing.Journal of the Pediatric Orthopaedic Society of North America · 2025Article
- Evaluation of risk factors associated with fragility fractures and recommendations to optimise bone health in children with long-term neurological condition.Singapore medical journal · 2023Article
- Pediatric Spina Bifida and Spinal Cord Injury.Journal of personalized medicine · 2022Article
- Health Concerns of Adolescents and Adults With Spina Bifida.Frontiers in neurology · 2021Article
- Quantitative Computed Tomography Assessment of Bone Deficits in Ambulatory Children and Adolescents with Spina Bifida: Importance of Puberty.JBMR plus · 2020Article
- Spina bifida-predisposing heterozygous mutations in Planar Cell Polarity genes and Zic2 reduce bone mass in young mice.Scientific reports · 2018Article
- Fat-Bone Interactions in Adults With Spina Bifida.Journal of the Endocrine Society · 2017Article
- Low Energy Availability, Menstrual Dysfunction, and Low Bone Mineral Density in Individuals with a Disability: Implications for the Para Athlete Population.Sports medicine (Auckland, N.Z.) · 2017Review
- Obesity Prevention for Individuals with Spina Bifida.Current obesity reports · 2017Review
- Who needs surgery for pediatric myelomeningocele? A retrospective study and literature review.The journal of spinal cord medicine · 2015Review
- An approach for determining quantitative measures for bone volume and bone mass in the pediatric spina bifida population.Clinical biomechanics (Bristol, Avon) · 2015Article
- Nutrition, metabolic syndrome, and obesity: Guidelines for the care of people with spina bifida.Journal of pediatric rehabilitation medicineReview
- Health promotion and preventive health care service guidelines for the care of people with spina bifida.Journal of pediatric rehabilitation medicineReview
Corrections and comments
- Erratum issuedMarreiros, Humberto Filipe [corrected to Marreiros, Humberto]
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
unlabelledThe prevalence and morbidity associated with osteoporosis and fractures in patients with spina bifida (SB) highlight the importance of osteoporosis prevention and treatment in early childhood; however, the issue has received little attention. The method for the selection of appropriate patients for drug treatment has not been clarified.
objectiveTo review the literature concerning fracture risks and low bone density in paediatric patients with SB. We looked for studies describing state-of-the-art treatments and for prevention of secondary osteoporosis.
methodsArticles were identified through a search in the electronic database (PUBMED) supplemented with reviews of the reference lists of selected papers. The main outcome measures were incidence of fractures and risk factors for fracture, an association between bone mineral density (BMD) and occurrence of fracture, risk factors of low BMD, and effects of pharmacological and non-pharmacological treatments on BMD and on the incidence of fractures. We considered as a secondary outcome the occurrence of fractures in relation to the mechanism of injury.
resultsResults indicated that patients with SB are at increased risk for fractures and low BMD. Risk factors that may predispose patients to fractures include higher levels of neurological involvement, non-ambulatory status, physical inactivity, hypercalciuria, higher body fat levels, contractures, and a previous spontaneous fracture. Limitations were observed in the number and quality of studies concerning osteoporosis prevention and treatment in paediatric patients with SB. The safety and efficiency of drugs to treat osteoporosis in adults have not been evaluated satisfactorily in children with SB.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.