ReviewMedicine and science in sports and exercise2012
Advances in exercise, fitness, and performance genomics in 2011.
Review in Medicine and science in sports and exercise, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 61 citations in OpenAlex.
- Genetics and athletic performance: a systematic SWOT analysis of non-systematic reviews.Frontiers in genetics · 2023Pooled it
- Association of the ACTN3 R577X (rs1815739) polymorphism with elite power sports: A meta-analysis.PloS one · 2019Pooled it
- Pre-Training Muscle Characteristics of Subjects Who Are Obese Determine How Well Exercise Training Will Improve Their Insulin Responsiveness.Journal of strength and conditioning research · 2017Trial
- Targeted Lipidomics and Inflammation Response to Six Weeks of Sprint Interval Training in Male Adolescents.International journal of environmental research and public health · 2023Article
- Prediction and Identification of Power Performance Using Polygenic Models of Three Single-Nucleotide Polymorphisms in Chinese Elite Athletes.Frontiers in genetics · 2021Article
- Genetic test for the personalization of sport training.Acta bio-medica : Atenei Parmensis · 2020Review
- Ethical Concerns in Sport: When the Will to Win Exceed the Spirit of Sport.Behavioral sciences (Basel, Switzerland) · 2018Review
- Article
- Sex-specific genetic effects in physical activity: results from a quantitative genetic analysis.BMC medical genetics · 2015Article
- Advances in exercise, fitness, and performance genomics in 2014.Medicine and science in sports and exercise · 2015Review
- Genetic variations underlying self-reported physical functioning: a review.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2015Review
- A genetic risk tool for obesity predisposition assessment and personalized nutrition implementation based on macronutrient intake.Genes & nutrition · 2015Article
- Quantitative genomics of voluntary exercise in mice: transcriptional analysis and mapping of expression QTL in muscle.Physiological genomics · 2014Article
- Genetic influence on exercise-induced changes in physical function among mobility-limited older adults.Physiological genomics · 2014Article
- Is gnb3 c825t polymorphism associated with elite status of polish athletes?Biology of sport · 2014Article
- Genes for elite power and sprint performance: ACTN3 leads the way.Sports medicine (Auckland, N.Z.) · 2013Review
- Endurance training enhances LXRα gene expression in Wistar male rats.European journal of applied physiology · 2013Article
- Genetic determinants of voluntary exercise.Trends in genetics : TIG · 2013Review
- Advances in exercise, fitness, and performance genomics in 2012.Medicine and science in sports and exercise · 2013Review
- Epigenetics in sports.Sports medicine (Auckland, N.Z.) · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 5 institutions in 4 countries.
Funding
Abstract
This review of the exercise genomics literature emphasizes the highest quality articles published in 2011. Given this emphasis on the best publications, only a small number of published articles are reviewed. One study found that physical activity levels were significantly lower in patients with mitochondrial DNA mutations compared with controls. A two-stage fine-mapping follow-up of a previous linkage peak found strong associations between sequence variation in the activin A receptor, type-1B (ACVRIB) gene and knee extensor strength, with rs2854464 emerging as the most promising candidate polymorphism. The association of higher muscular strength with the rs2854464 A allele was confirmed in two separate cohorts. A study using a combination of transcriptomic and genomic data identified a comprehensive map of the transcriptomic features important for aerobic exercise training-induced improvements in maximal oxygen consumption, but no genetic variants derived from candidate transcripts were associated with trainability. A large-scale de novo meta-analysis confirmed that the effect of sequence variation in the fat mass and obesity-associated (FTO) gene on the risk of obesity differs between sedentary and physically active adults. Evidence for gene-physical activity interactions on type 2 diabetes risk was found in two separate studies. A large study of women found that physical activity modified the effect of polymorphisms in the lipoprotein lipase (LPL), hepatic lipase (LIPC), and cholesteryl ester transfer protein (CETP) genes, identified in previous genome-wide association study reports, on HDL cholesterol. We conclude that a strong exercise genomics corpus of evidence would not only translate into powerful genomic predictors but also have a major effect on exercise biology and exercise behavior research.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.