ArticleConnective tissue research2012
Regional variation in human supraspinatus tendon proteoglycans: decorin, biglycan, and aggrecan.
Article in Connective tissue research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Proteomics perspectives in rotator cuff research: a systematic review of gene expression and protein composition in human tendinopathy.PloS one · 2015Pooled it
- The Biomechanical, Biochemical, and Morphological Properties of 31 Human Cadaveric Upper Limb Tendons: An Open Access Data Set.Orthopaedic journal of sports medicine · 2026Article
- Neuromechanical basis of region-specific differences and their implications for sport performance and injury prevention: a narrative review.European journal of applied physiology · 2025Review
- Structural Motifs in Soft Fibrous Tissues: Revealing Structure-Mechanics Relationships in Deformation and Tear Resistance for Biomimetic Material Design.Advanced healthcare materials · 2025Review
- Mature murine supraspinatus tendons demonstrate regional differences in multiscale structure, function and gene expression.PloS one · 2025Article
- Macrophage polarization and macrophage-related factor expression in hypertrophy of the ligamentum flavum.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2024Article
- Murine Hind Limb Explant Model for Studying the Mechanobiology of Achilles Tendon Impingement.Journal of visualized experiments : JoVE · 2023Article
- Bioactive extracellular matrix fragments in tendon repair.Cell and tissue research · 2022Review
- The Role of the Non-Collagenous Extracellular Matrix in Tendon and Ligament Mechanical Behavior: A Review.Journal of biomechanical engineering · 2022Review
- Tissue-specific parameters for the design of ECM-mimetic biomaterials.Acta biomaterialia · 2021Review
- Contribution of extracellular matrix components to the stiffness of skeletal muscle contractures in patients with cerebral palsy.Connective tissue research · 2021Article
- Decorin Regulates the Aggrecan Network Integrity and Biomechanical Functions of Cartilage Extracellular Matrix.ACS nano · 2019Article
- Decorin-supplemented collagen hydrogels for the co-delivery of bone morphogenetic protein-2 and microvascular fragments to a composite bone-muscle injury model with impaired vascularization.Acta biomaterialia · 2019Article
- Multiscale Mechanical Evaluation of Human Supraspinatus Tendon Under Shear Loading After Glycosaminoglycan Reduction.Journal of biomechanical engineering · 2017Article
- Tendon exhibits complex poroelastic behavior at the nanoscale as revealed by high-frequency AFM-based rheology.Journal of biomechanics · 2017Article
- Modelling approaches for evaluating multiscale tendon mechanics.Interface focus · 2016Article
- Achilles tendons from decorin- and biglycan-null mouse models have inferior mechanical and structural properties predicted by an image-based empirical damage model.Journal of biomechanics · 2015Article
- Regulatory role of collagen V in establishing mechanical properties of tendons and ligaments is tissue dependent.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2015Article
- Exploiting cell-mediated contraction and adhesion to structure tissues in vitro.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2015Article
- Thyroid hormones increase collagen I and cartilage oligomeric matrix protein (COMP) expression in vitro human tenocytes.Muscles, ligaments and tendons journal · 2014Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
While tendons typically undergo primary tensile loading, the human supraspinatus tendon (SST) experiences substantial amounts of tension, compression, and shear in vivo. As a result, the functional roles of the extracellular matrix components, in particular the proteoglycans (PGs), are likely complex and important. The goal of this study was to determine the PG content in specific regions of the SST that exhibit differing mechanical function. The concentration of aggrecan, biglycan, and decorin was determined in six regions of the human SST using immunochemical techniques. We hypothesized that aggrecan concentrations would be highest in areas where the tendon likely experiences compression; biglycan levels would be highest in regions likely subjected to injury and/or active remodeling such as the anterior regions; decorin concentrations would be highest in regions of greatest tensile stiffness. Our results generally supported these hypotheses and demonstrated that aggrecan and biglycan share regional variability, with increased concentration in the anterior and posterior regions and smaller concentration in the medial regions. Decorin, however, was in high concentration throughout all regions. The data presented in this study represent the first regional measurements of PG in the SST. Together with our previous regional measurements of mechanical properties, these data can be used to evaluate SST structure-function relationships. With knowledge of the differences in specific PG content, their spatial variations in the SST, and their relationships to tendon mechanics, we can begin to associate defects in PG content with specific pathology, which may provide guidance for new therapeutic interventions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.