ArticleJournal of the American Chemical Society2012
Two separate gene clusters encode the biosynthetic pathway for the meroterpenoids austinol and dehydroaustinol in Aspergillus nidulans.
Article in Journal of the American Chemical Society, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 106 papers.
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Who cites it
106 citing papers in PubMed.
- Discovery of Pyranoquinolone Diterpenoids Biosynthesized through Oxidative Indole Rearrangement and Atypical Terpene Cyclization.Journal of the American Chemical Society · 2026Article
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- Identification of Marine-Derived Compounds with Potent Antiviral Activity in a Recombinant HBV cccDNA Cell Model.ACS omega · 2026Article
- Complete biosynthesis of phenylspirodrimanes with unclustered genes inActa pharmaceutica Sinica. B · 2026Article
- The VelB IDD promotes selective heterodimer formation of velvet proteins for fungal development.Life science alliance · 2026Article
- Functional dissection of velvet DNA-binding region inIMA fungus · 2026Article
- Molecular circuit between Aspergillus nidulans transcription factors MsnA and VelB to coordinate fungal stress and developmental responses.PLoS genetics · 2025Article
- Biosynthesis of the Paecilomyces marquandii conidial pigment saintopin.Fungal biology and biotechnology · 2025Article
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- Discovery of Noncanonical Iron and 2-Oxoglutarate Dependent Enzymes Involved in C-C and C-N Bond Formation in Biosynthetic Pathways.ACS bio & med chem Au · 2025Review
- Antimicrobial Compounds FromInternational journal of microbiology · 2025Article
- Class II terpene cyclases: structures, mechanisms, and engineering.Natural product reports · 2024Review
- Global genome mining-driven discovery of an unusual biosynthetic logic for fungal polyketide-terpenoid hybrids.Chemical science · 2024Article
- Austin-Type Meroterpenoids from Fungi Reported in the Last Five Decades: A Review.Journal of fungi (Basel, Switzerland) · 2024Review
- Identification of the oosporein biosynthesis gene cluster in an entomopathogenic fungusMycoscience · 2024Article
- Production of non-natural 5-methylorsellinate-derived meroterpenoids inBeilstein journal of organic chemistry · 2024Article
- Phytochemical analysis and anti-infective potential of fungal endophytes isolated from Nigella sativa seeds.BMC microbiology · 2023Article
- Molecular networking as a tool to annotate the metabolites of3 Biotech · 2023Article
46 more citing papers are in PubMed but not listed here.
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9 authors.
Funding
Abstract
Meroterpenoids are a class of fungal natural products that are produced from polyketide and terpenoid precursors. An understanding of meroterpenoid biosynthesis at the genetic level should facilitate engineering of second-generation molecules and increasing production of first-generation compounds. The filamentous fungus Aspergillus nidulans has previously been found to produce two meroterpenoids, austinol and dehydroaustinol. Using targeted deletions that we created, we have determined that, surprisingly, two separate gene clusters are required for meroterpenoid biosynthesis. One is a cluster of four genes including a polyketide synthase gene, ausA. The second is a cluster of 10 additional genes including a prenyltransferase gene, ausN, located on a separate chromosome. Chemical analysis of mutant extracts enabled us to isolate 3,5-dimethylorsellinic acid and 10 additional meroterpenoids that are either intermediates or shunt products from the biosynthetic pathway. Six of them were identified as novel meroterpenoids in this study. Our data, in aggregate, allow us to propose a complete biosynthetic pathway for the A. nidulans meroterpenoids.
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