Evidence map›Paper›PMID 22329667›Full record

Trial reportActa orthopaedica2012

The beneficial effect of hydroxyapatite lasts: a randomized radiostereometric trial comparing hydroxyapatite-coated, uncoated, and cemented tibial components for up to 16 years.

Bart G Pijls, Edward R Valstar, Bart L Kaptein, Marta Fiocco, Rob G H H Nelissen

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Acta orthopaedica, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
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  5. Pooled it
  6. Trial
  7. Uncemented or cemented femoral components work equally well in total knee arthroplasty.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2019
    Trial
  8. Trial
  9. Trial
  10. Review
  11. New Horizons of Cementless Total Knee Arthroplasty.Journal of clinical medicine · 2023
    Review
  12. Review
  13. Article
  14. Article
  15. Article
  16. Good long-term results following cementless TKA with a titanium plasma coating.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2017
    Article
  17. Article
  18. Article
  19. Radiostereometry and new prostheses.Acta orthopaedica · 2012
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Bart G PijlsBio Imaging Group, Department of Orthopaedics, Leiden University Medical Center, the Netherlands. b.g.c.w.pijls@lumc.nl
Edward R Valstar
Bart L Kaptein
Marta Fiocco
Rob G H H Nelissen

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeIn contrast to early migration, the long-term migration of hydroxyapatite- (HA-) coated tibial components in TKA has been scantily reported. This randomized controlled trial investigated the long-term migration measured by radiostereometric analysis (RSA) of HA-coated, uncoated, and cemented tibial components in TKA. PATIENTS AND

methods68 knees were randomized to HA-coated (n = 24), uncoated (n = 20), and cemented (n = 24) components. All knees were prospectively followed for 11-16 years, or until death or revision. RSA was used to evaluate migration at yearly intervals. Clinical and radiographic evaluation was according to the Knee Society system. A generalized linear mixed model (GLMM, adjusted for age, sex, diagnosis, revisions, and BMI) was used to take into account the repeated-measurement design.

resultsThe present study involved 742 RSA analyses. The mean migration at 10 years was 1.66 mm for HA, 2.25 mm for uncoated and 0.79 mm for the cemented group (p < 0.001). The reduction of migration by HA as compared to uncoated components was most pronounced for subsidence and external rotation. 3 tibial components were revised for aseptic loosening (2 uncoated and 1 cemented), 3 for septic loosening (2 uncoated and 1 cemented), and 1 for instability (HA-coated). 2 of these cases were revised for secondary loosening after a period of stability: 1 case of osteolysis and 1 case of late infection. There were no statistically significant differences between the fixation groups regarding clinical or radiographic scores.

interpretationHA reduces migration of uncemented tibial components. This beneficial effect lasts for more than 10 years. Cemented components showed the lowest migration. Longitudinal follow-up of TKA with RSA allows early detection of secondary loosening.

Indexed as

Bone CementsDurapatiteKnee ProsthesisProsthesis FailureRadiostereometric AnalysisAgedAged, 80 and overArthritis, RheumatoidArthroplasty, Replacement, KneeFemaleFollow-Up StudiesHumansKnee JointLongitudinal StudiesMaleMiddle AgedBone CementsDurapatite

Identifiers

PMID22329667
PMCPMC3339526

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.