ReviewCurrent Alzheimer research2012
Chronobiological approaches to Alzheimer's disease.
Review in Current Alzheimer research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 27 citations in OpenAlex.
- Lifestyle factors associated with episodic memory in middle-aged and older adults: evidence from a 9-year longitudinal study.BMC public health · 2024Article
- Beyond Conventional Therapies: Molecular Dynamics of Alzheimer's Treatment through CLOCK/BMAL1 Interactions.Current Alzheimer research · 2024Article
- Association between all-cause mortality and trajectories across quality and duration of sleep and cognitive function: based on Group-Based Multivariate Trajectory modeling.BMC geriatrics · 2023Article
- Neural function of Bmal1: an overview.Cell & bioscience · 2023Review
- Gait Speed and Sleep Duration Is Associated with Increased Risk of MCI in Older Community-Dwelling Adults.International journal of environmental research and public health · 2022Article
- Reversible Suppression of Fear Memory Recall by Transient Circadian Arrhythmia.Frontiers in integrative neuroscience · 2022Article
- Sex, Sleep Duration, and the Association of Cognition: Findings from the China Health and Retirement Longitudinal Study.International journal of environmental research and public health · 2021Article
- Disruption of circadian timing increases synaptic inhibition and reduces cholinergic responsiveness in the dentate gyrus.Hippocampus · 2021Article
- Decreased circadian fluctuation in cognitive behaviors and synaptic plasticity in APP/PS1 transgenic mice.Metabolic brain disease · 2020Article
- Circadian disruption and human health: A bidirectional relationship.The European journal of neuroscience · 2020Review
- The relationship between sleep duration, cognition and dementia: a Mendelian randomization study.International journal of epidemiology · 2019Article
- Behavioral and SCN neurophysiological disruption in the Tg-SwDI mouse model of Alzheimer's disease.Neurobiology of disease · 2018Article
- Interactions Among Polymorphisms of Susceptibility Loci for Alzheimer's Disease or Depressive Disorder.Medical science monitor : international medical journal of experimental and clinical research · 2018Article
- Clinical management of sleep disturbances in Alzheimer's disease: current and emerging strategies.Nature and science of sleep · 2016Review
- Local receptors as novel regulators for peripheral clock expression.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Dynamic circadian rhythms contribute to memory formation, and the hormonal and neurochemical changes that follow circadian patterns are frequently dysregulated with aging. The effect of aging on circadian rhythms is a double-edged sword; on one hand, poor sleep quality compromises neuronal structure and function in regions that support cognition, and on the other hand, perturbation of central and peripheral oscillators changes the hormonal milieu, with consequences for neuroplasticity. In the current review, recent developments surrounding the circadian regulation of memory formation are described, with reference to how mechanisms that support temporal coding might change with advancing age. The cognitive consequences of changes in sleep patterns are also discussed. New roles for the circadian clock genes period-1, period-2, and bmal1 in memory formation are discussed in the context of age-related cognitive decline. The potential for chronobiological approaches to the treatment and prevention of Alzheimer's disease merits further exploration from a pharmacotherapeutic perspective, as the timing of drug delivery could potentiate or diminish treatment efficacy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.