ArticleBipolar disorders2012
Olfactory acuity is associated with mood and function in a pilot study of stable bipolar disorder patients.
Article in Bipolar disorders, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 49 citations in OpenAlex.
- Taste dysfunction as a predictor of depression in schizophrenia: A systematic review and meta-analysis.PloS one · 2024Pooled it
- Olfaction and Executive Cognitive Performance: A Systematic Review.Frontiers in psychology · 2022Pooled it
- APOE ε4 carriage is associated with olfactory-hippocampal tract functional connectivity.Brain imaging and behavior · 2026Article
- Changes in olfactory function and serum interleukin-6 levels in the acute phase of bipolar I disorder: a longitudinal study.BMC psychiatry · 2025Article
- Association between olfactory function and metabolic syndrome in bipolar disorder patients: a cross-sectional study.BMC psychiatry · 2024Article
- Significant improvements in the olfactory sensitivity of bipolar I disorder patients during euthymia versus manic episodes: a longitudinal study.Frontiers in psychiatry · 2024Article
- Comparison of olfactory function, cognitive function and serum tumor necrosis factor-α between bipolar and schizophrenic patients in the remission stage.BMC psychiatry · 2023Article
- Impaired olfactory function in bipolar disorder patients during acute episodes regardless of psychotic symptoms.Frontiers in psychiatry · 2023Article
- Variations in olfactory function among bipolar disorder patients with different episodes and subtypes.Frontiers in psychiatry · 2023Article
- Olfactory modulation of the medial prefrontal cortex circuitry: Implications for social cognition.Seminars in cell & developmental biology · 2022Review
- The Role of TRPA1 Channels in the Central Processing of Odours Contributing to the Behavioural Responses of Mice.Pharmaceuticals (Basel, Switzerland) · 2021Article
- Reduced odor detection and hedonic changes in asymptomatic university students as SARS-CoV-2 emerged locally.medRxiv : the preprint server for health sciences · 2020Article
- Article
- Sex differences in hedonic judgement of odors in schizophrenia cases and healthy controls.Psychiatry research · 2018Article
- Olfactory Functioning in First-Episode Psychosis.Schizophrenia bulletin · 2018Article
- Olfactory Functioning and Depression: A Systematic Review.Frontiers in psychiatry · 2017Review
- Methods to measure olfactory behavior in mice.Current protocols in toxicology · 2015Article
- Increased doublecortin (DCX) expression and incidence of DCX-immunoreactive multipolar cells in the subventricular zone-olfactory bulb system of suicides.Frontiers in neuroanatomy · 2015Article
- Brain structural imaging correlates of olfactory dysfunction in obsessive-compulsive disorder.European archives of psychiatry and clinical neuroscience · 2014Article
- Derivation of neural stem cells from an animal model of psychiatric disease.Translational psychiatry · 2013Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
Abstract
objectivesOlfactory dysfunction is described in several neuropsychiatric disorders but there is little research on olfactory processing in bipolar disorder.
methodsWe assessed odor detection threshold (sensitivity) and smell identification test scores, along with symptoms, cognition, and social function in 20 DSM-IV bipolar disorder patients and 44 control subjects.
resultsThe patient and control groups had similar demographic measures, intelligence, and mean olfaction scores, but significantly differed in social domains, including adjustment, function, and anxiety. Odor detection sensitivity showed significantly opposite correlations for the depressive and manic mood domains in bipolar disorder (r to z = 2.83, p = 0.005). Depressive symptoms were related to increased sensitivity (the ability to detect odors at a lower concentration) and mania symptoms were related to decreased sensitivity for odor detection. Increased sensitivity for odor detection also predicted significantly better employment (r = -0.642, p = 0.024), whereas less sensitivity was associated with social avoidance (r = 0.702, p =0.024) and social fear (r = 0.610, p = 0.046).
conclusionsDiminished odor detection sensitivity predicted mania and social avoidance, whereas more sensitive odor detection predicted more depressive symptoms but better employment functioning in bipolar disorder patients. Odor acuity may be an illness state marker of mood syndromes in bipolar disorder. Alternatively, differences in odor acuity may identify heterogeneous subgroups within the bipolar spectrum. Longitudinal assessments in a large, sex-stratified sample are needed to understand the implications of odor sensitivity in patients with bipolar disorder.
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