ArticleBipolar disorders2012
Cigarette smoking and its relationship to mood disorder symptoms and co-occurring alcohol and cannabis use disorders following first hospitalization for bipolar disorder.
Article in Bipolar disorders, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 36 citations in OpenAlex.
- Smoking cessation for improving mental health.The Cochrane database of systematic reviews · 2021Pooled it
- Associations between health risk behaviors and symptoms of schizophrenia and bipolar disorder: a systematic review.General hospital psychiatryPooled it
- Association of pediatric bipolar disorder and substance use disorder in adulthood in a prospective cohort.Journal of affective disorders · 2026Article
- Risk for alcohol use problems in severe mental illness: Interactions with sex and racial/ethnic minority status.Journal of affective disorders · 2023Article
- Cigarette smoking and risk of suicide in bipolar disorder: a systematic review.Frontiers in psychiatry · 2023Review
- Substance Misuse Trajectories and Risk of Relapse in the Early Course of Bipolar Disorder.Frontiers in psychiatry · 2021Article
- Bipolar Disorder Associated with Another Autoimmune Disease-Pemphigus: A Population-based Study.Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2018Article
- Triple trajectories of alcohol use, tobacco use, and depressive symptoms as predictors of cannabis use disorders among urban adults.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2018Article
- Does the number of previous mood episodes moderate the relationship between alcohol use, smoking and mood in bipolar outpatients?BMC psychiatry · 2017Article
- Impact of Cannabis Use on Long-Term Remission in Bipolar I and Schizoaffective Disorder.Psychiatry investigation · 2015Article
- Continued cannabis use at one year follow up is associated with elevated mood and lower global functioning in bipolar I disorder.BMC psychiatry · 2015Article
- Risk and protective factors associated with substance use disorders in adolescents with first-episode mania.Journal of the American Academy of Child and Adolescent Psychiatry · 2014Article
- Prevalence and correlates of heavy smoking and nicotine dependence in adolescents with bipolar and cannabis use disorders.Psychiatry research · 2013Article
- Temporal sequencing of nicotine dependence and bipolar disorder in the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC).Journal of psychiatric research · 2013Article
- Tobacco use treatment in primary care patients with psychiatric illness.Journal of the American Board of Family Medicine : JABFMReview
- Treatment of tobacco use disorders in smokers with serious mental illness: toward clinical best practices.Harvard review of psychiatryReview
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
objectivesCigarette smoking is highly prevalent among individuals with bipolar disorder (BD) and may adversely affect symptoms of the disorder, as well as the co-occurrence of other substance use disorders. However, anecdotal reports suggesting that smoking cessation caused a worsening of mood in smokers with BD have raised concerns about quitting. In the present study, we prospectively evaluated the course of BD, alcohol use disorders, and cannabis use disorders in relation to smoking and examined the relationship between smoking abstinence and changes in mood.
methodsParticipants (N = 161) were adolescents (n=80) and adults (n = 81) with bipolar I disorder who were hospitalized for their initial mixed or manic episode. Participants were followed up to eight years post-hospitalization (median follow-up = 122 weeks) as part of a naturalistic, observational study of the longitudinal course of BD and substance use.
resultsThe course of BD symptoms in the 12 months following index hospitalization did not differ by smoking status in either the adolescent or the adult subsample. Among adolescents, smoking was associated with an increased risk of having a cannabis or alcohol use disorder, almost all of which were new-onset disorders, in the year following first hospitalization. Neither adolescents nor adults who were abstinent from smoking for at least two months experienced significant increases in depressive or manic symptoms.
conclusionsAlthough cigarette smoking did not predict a worse course of BD, smoking was associated with an increased risk of developing alcohol and cannabis use disorders in adolescents with BD. Importantly, these data provide no evidence to suggest that abstinence from smoking is associated with worsening symptoms of depression or mania in the short term.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.