ArticleBipolar disorders2012
Pollen-specific immunoglobulin E positivity is associated with worsening of depression scores in bipolar disorder patients during high pollen season.
Article in Bipolar disorders, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00770068 (Seasonality of Depression and Airborne Allergens), which is not on this map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Seasonality of Depression and Airborne Allergens
Who cites it
15 citing papers in PubMed, 36 citations in OpenAlex.
- Toxoplasma gondii and suicidal behaviour: discovery, cross-diagnostic confirmation and pathway exploration.Folia parasitologica · 2025Article
- A Unified Pathogenesis of Allergic Diseases; The Protein-Homeostasis-System Hypothesis.International journal of molecular sciences · 2025Review
- Pollen effects in a changing climate: Ragweed pollen exposure and sleepiness in immunotherapy patients of a Southeastern Michigan allergy clinic.International journal of biometeorology · 2024Article
- Immune-Targeted Therapies for Depression: Current Evidence for Antidepressant Effects of Monoclonal Antibodies.The Journal of clinical psychiatry · 2024Review
- Comparison of Immune and Systemic Inflammation Parameters in Patients with a Depressive Episode in Bipolar Disorder and Major Depressive Disorder: A Scoping Review.Consortium psychiatricum · 2024Review
- Higher rates of allergies, autoimmune diseases and low-grade inflammation markers in treatment-resistant major depression.Brain, behavior, & immunity - health · 2021Article
- Clinical characteristics and sociodemographic features of psychotic major depression.Annals of general psychiatry · 2021Article
- Review
- Allergies, asthma, and psychopathology in a nationally-representative US sample.Journal of affective disorders · 2019Article
- Mood Worsening on Days with High Pollen Counts is associated with a Summer Pattern of Seasonality.Pteridines · 2019Article
- Mental Health in Allergic Rhinitis: Depression and Suicidal Behavior.Current treatment options in allergy · 2017Article
- Phadiatop Seropositivity in Schizophrenia Patients and Controls: A Preliminary Study.AIMS public health · 2014Article
- Suicide risk in relation to air pollen counts: a study based on data from Danish registers.BMJ open · 2013Article
- Seasonality of suicidal behavior.International journal of environmental research and public health · 2012Review
- Rhinitis as an associated factor for anxiety and depression amongst adults.Brazilian journal of otorhinolaryngologyArticle
Corrections and comments
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Authors and funding
16 authors at 5 institutions in 1 country.
Funding
Abstract
objectiveAn association between allergic disease and depression has been consistently reported, but whether the key mediating ingredients are predominantly biological, psychological, or mere artifacts remains unknown. In the current study, we examined a hypothesized relationship between allergen-specific immunoglobulin E (IgE) status and changes in allergy symptoms with worsening in depression scores.
methodsIn patients with recurrent mood disorders, we individually coupled sensitization to specific seasonal aeroallergens (as assessed by allergen-specific IgE) with temporal windows of exposure to aeroallergens (low versus high tree or ragweed pollen counts, measured according to the National Allergy Bureau guidelines). We compared Structured Interview Guide for the Hamilton Depression Rating Scale-Seasonal Affective Disorder Version (SIGH-SAD) depression score changes in 41 patients with mood disorders [25 with major depression and 16 with bipolar I disorder, diagnosed by Structured Clinical Interview for DSM (SCID)] seropositive for tree or ragweed pollen-specific IgE antibody versus 53 patients with mood disorders (30 with major depression and 23 with bipolar I disorder) seronegative for aeroallergen-specific IgE.
resultsWorsening in total depressive scores from low to high pollen exposure was greater in allergen-specific IgE-positive patients as compared to allergen-specific IgE antibody-negative patients (p = 0.01). When stratified by polarity, the association was significant only in patients with bipolar I disorder (p = 0.004). This relationship was resilient to adjustment for changes in allergy symptom scores.
conclusionTo our knowledge, this is the first report of coupling a molecular marker of vulnerability (allergen-specific IgE) with a specific environmental trigger (airborne allergens) leading to exacerbation of depression in patients with bipolar I disorder.
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