ArticleBipolar disorders2012
Relationship between suicidality and impulsivity in bipolar I disorder: a diffusion tensor imaging study.
Article in Bipolar disorders, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 4 of them syntheses that pooled it.
What it found
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Who cites it
44 citing papers in PubMed, 4 syntheses or guidelines pooled it, 129 citations in OpenAlex.
- Structural connectivity abnormalities in suicidal thoughts and behaviours: a meta-analysis.Translational psychiatry · 2025Pooled it
- The association between white matter hyperintensities and suicide attempts in affective disorders: a systematic review and meta-analysis.Translational psychiatry · 2025Pooled it
- Psychoradiologic abnormalities of white matter in patients with bipolar disorder: diffusion tensor imaging studies using tract-based spatial statisticsJournal of psychiatry & neuroscience : JPN · 2019Pooled it
- Epidemiology, neurobiology and pharmacological interventions related to suicide deaths and suicide attempts in bipolar disorder: Part I of a report of the International Society for Bipolar Disorders Task Force on Suicide in Bipolar Disorder.The Australian and New Zealand journal of psychiatry · 2015Pooled it
- Efficacy and Safety of Transcranial Direct Current Stimulation as an Add-On Trial Treatment for Acute Bipolar Depression Patients With Suicidal Ideation.CNS neuroscience & therapeutics · 2024Trial
- Impulsivity, emotional dysregulation, aggression, and hopelessness in suicide attempts among bipolar disorder patients: A cross sectional study.Indian journal of psychiatry · 2026Article
- Transdiagnostic alterations in white matter microstructure associated with suicidal thoughts and behaviours in the ENIGMA Suicidal Thoughts and Behaviours consortium.Translational psychiatry · 2025Article
- An observational study on gray matter volume and white matter integrity in suicide attempters with bipolar I disorder.Indian journal of psychiatry · 2025Article
- Mood disorders and suicide: pilot study on postmortem toxicologic evidence and adherence to psychiatric therapy by determining blood levels of medications.International journal of legal medicine · 2025Article
- The mediation effects of nightmares and depression between insomnia and suicidal ideation in young adults.Scientific reports · 2024Article
- Disrupted white matter microstructure correlates with impulsivity in children and adolescents with bipolar disorder.Journal of psychiatric research · 2023Article
- Modeling Suicidality with Multimodal Impulsivity Characterization in Participants with Mental Health Disorder.Behavioural neurology · 2023Article
- Diffusion tensor imaging studies on subjects with suicidal thoughts and behaviors: A descriptive literature review.Brain and behavior · 2022Review
- Rethinking "aggression" and impulsivity in bipolar disorder: Risk, clinical and brain circuitry features.Journal of affective disorders · 2022Article
- Distinct patterns of altered quantitative T1ρ and functional BOLD response associated with history of suicide attempts in bipolar disorder.Brain imaging and behavior · 2022Article
- Exploring neurometabolic alterations in bipolar disorder with suicidal ideation based on proton magnetic resonance spectroscopy and machine learning technology.Frontiers in neuroscience · 2022Article
- Altered Levels of Plasma Inflammatory Cytokines and White Matter Integrity in Bipolar Disorder Patients With Suicide Attempts.Frontiers in psychiatry · 2022Article
- Article
- Association of Prefrontal Cortex Thinning with High Impulsivity in Healthy Adults.Psychiatry investigation · 2021Article
- White Matter Correlates of Suicidality in Adults With Bipolar Disorder Who Have Been Prospectively Characterized Since Childhood.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2021Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundImpulsivity is characteristic of individuals with bipolar disorder and may be a contributing factor to the high rate of suicide in patients with this disorder. Although white matter abnormalities have been implicated in the pathophysiology of bipolar disorder, their relationship to impulsivity and suicidality in this disorder has not been well-investigated.
methodsDiffusion tensor imaging scans were acquired in 14 bipolar disorder patients with a prior suicide attempt, 15 bipolar disorder patients with no prior suicide attempt, and 15 healthy volunteers. Bipolar disorder patients received clinical assessments including measures of impulsivity, depression, mania, and anxiety. Images were processed using the Tract-Based Spatial Statistics method in the FSL software package.
resultsBipolar disorder patients with a prior suicide attempt had lower fractional anisotropy (FA) within the left orbital frontal white matter (p < 0.05, corrected) and higher overall impulsivity compared to patients without a previous suicide attempt. Among patients with a prior suicide attempt, FA in the orbital frontal white matter region correlated inversely with motor impulsivity.
conclusionsAbnormal orbital frontal white matter may play a role in impulsive and suicidal behavior among patients with bipolar disorder.
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