Evidence map›Paper›PMID 2232941›Full record

ReviewMedical oncology and tumor pharmacotherapy1990

Dietary carcinogens, environmental pollution, and cancer: some misconceptions.

B N Ames, L S Gold

Abstract readReview
PubMed Publisher
In one paragraph

Review in Medical oncology and tumor pharmacotherapy, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

B N AmesDivision of Biochemistry and Molecular Biology, University of California, Berkeley 94720.
L S Gold
University of California, Berkeley · US

Funding

VIROLOGY AND CHRONIC INFECTIONP30ES001896 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI SMITH, MARTYN T · 1985 to 2003
$4.7M
MUTAGENESIS AND CARCINOGENESISR35CA039910 · NCI · UNIVERSITY OF CALIFORNIA BERKELEY · PI AMES, BRUCE N · 1985 to 1998
–
NCI NIH HHS CA39910NIEHS NIH HHS 222-Y01-ES-10066NIEHS NIH HHS ES01896
6 · The paper itself

Abstract

Various misconceptions about dietary carcinogens, pesticide residues, and cancer causation are discussed. The pesticides in our diet are 99.99% natural, since plants make an enormous variety of toxins against fungi, insects, and animal predators. Although only 50 of these natural pesticides have been tested in animal cancer tests, about half of them are carcinogens. About half of all chemicals tested in animal cancer tests are positive. The proportion of natural pesticides positive in animal tests of clastogenicity is also the same as for synthetic chemicals. It is argued that testing chemicals in animals at the maximum tolerated dose primarily measures chronic cell proliferation, a threshold process. Cell proliferation is mutagenic in several ways, including inducing mitotic recombination, and therefore chronic induction of cell proliferation is a risk factor for cancer.

Indexed as

CarcinogensAnimalsDietEnvironmental PollutionFoodFood AnalysisHumansMutagenicity TestsNeoplasmsNeoplasms, ExperimentalPesticidesRodentiaCarcinogensPesticides

Identifiers

PMID2232941
OpenAlexW1493463462

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.