ArticleEnvironmental health perspectives2012
A prospective study of organochlorines in adipose tissue and risk of non‑Hodgkin lymphoma.
Article in Environmental health perspectives, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 53 citations in OpenAlex.
- Insecticide use and risk of non-Hodgkin lymphoma subtypes: A subset meta-analysis of the North American Pooled Project.International journal of cancer · 2020Pooled it
- Exposure to organochlorine pesticides and non-Hodgkin lymphoma: a meta-analysis of observational studies.Scientific reports · 2016Pooled it
- Blood LeukocyteCancer research communications · 2023Article
- Etiology of non-Hodgkin lymphoma: A review from epidemiologic studies.Journal of the National Cancer Center · 2022Review
- Prediagnostic serum concentrations of organochlorine pesticides and non-Hodgkin lymphoma: A nested case-control study in the Norwegian Janus Serum Bank Cohort.Environmental research · 2020Article
- Childhood Residential and Agricultural Pesticide Exposures in Relation to Adult-Onset Rheumatoid Arthritis in Women.American journal of epidemiology · 2018Article
- Prediagnostic plasma concentrations of organochlorines and risk of B-cell non-Hodgkin lymphoma in envirogenomarkers: a nested case-control study.Environmental health : a global access science source · 2017Article
- Mortality among capacitor workers exposed to polychlorinated biphenyls (PCBs), a long-term update.International archives of occupational and environmental health · 2015Article
- Non-hodgkin lymphoma risk and insecticide, fungicide and fumigant use in the agricultural health study.PloS one · 2014Article
- Multidrug resistance 1 gene variants, pesticide exposure, and increased risk of DNA damage.BioMed research international · 2014Article
- Residence proximity to benzene release sites is associated with increased incidence of non-Hodgkin lymphoma.Cancer · 2013Article
- Lifetime pesticide use and telomere shortening among male pesticide applicators in the Agricultural Health Study.Environmental health perspectives · 2013Article
- Household endotoxin levels and the risk of non-Hodgkin lymphoma.Cancer causes & control : CCC · 2013Article
- Inhibition of human MDR1 and BCRP transporter ATPase activity by organochlorine and pyrethroid insecticides.Journal of biochemical and molecular toxicology · 2013Article
- Article
- Current understanding of lifestyle and environmental factors and risk of non-hodgkin lymphoma: an epidemiological update.Journal of cancer epidemiology · 2012Article
- Predictors of adipose tissue concentrations of organochlorine pesticides in a general Danish population.Journal of exposure science & environmental epidemiologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundExposure to organochlorines has been examined as a potential risk factor for non-Hodgkin lymphoma (NHL), with inconsistent results that may be related to limited statistical power or to imprecise exposure measurements.
objectiveOur purpose was to examine associations between organochlorine concentrations in prediagnostic adipose tissue samples and the risk of NHL.
methodsWe conducted a case–cohort study using a prospective Danish cohort of 57,053 persons enrolled between 1993 and 1997. Within the cohort we identified 256 persons diagnosed with NHL in the population-based nationwide Danish Cancer Registry and randomly selected 256 subcohort persons. We measured concentrations of 8 pesticides and 10 polychlorinated biphenyl (PCB) congeners in adipose tissue collected upon enrollment. Associations between the 18 organochlorines and NHL were analyzed in Cox regression models, adjusting for body mass index.
resultsIncidence rate ratios and confidence intervals (CIs) for interquartile range increases in concentrations of dichlorodiphenyltrichlorethane (DDT), cis-nonachlor, and oxychlordane were 1.35 (95% CI: 1.10, 1.66), 1.13 (95% CI: 0.94, 1.36), and 1.11 (95% CI: 0.89, 1.38), respectively, with monotonic dose–response trends for DDT and cis-nonachlor based on categorical models. The relative risk estimates were higher for men than for women. In contrast, no clear association was found between NHL and PCBs.
conclusionWe found a higher risk of NHL in association with higher adipose tissue levels of DDT, cis-nonachlor, and oxychlordane, but no association with PCBs. This is the first study of organochlorines and NHL using prediagnostic adipose tissue samples in the exposure assessment and provides new environmental health evidence that these organochlorines contribute to NHL risk.
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