ArticlePloS one2012
Incorporation of a horizontally transferred gene into an operon during cnidarian evolution.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 23 citations in OpenAlex.
- Genetic interference with HvNotch provides new insights into the role of the Notch-signalling pathway for developmental pattern formation in Hydra.Scientific reports · 2024Article
- A chromosome-scale epigenetic map of theGenome research · 2023Article
- Transgenesis in Hydra to characterize gene function and visualize cell behavior.Nature protocols · 2019Article
- Article
- Non-overlapping Neural Networks in Hydra vulgaris.Current biology : CB · 2017Article
- Generation of transgenic Hydra by embryo microinjection.Journal of visualized experiments : JoVE · 2014Article
- Operons are a conserved feature of nematode genomes.Genetics · 2014Article
- PIWI proteins and PIWI-interacting RNAs function in Hydra somatic stem cells.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Bioinformatics analysis of bacterial annexins--putative ancestral relatives of eukaryotic annexins.PloS one · 2014Article
- A small molecule screen identifies a novel compound that induces a homeotic transformation in Hydra.Development (Cambridge, England) · 2013Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Genome sequencing has revealed examples of horizontally transferred genes, but we still know little about how such genes are incorporated into their host genomes. We have previously reported the identification of a gene (flp) that appears to have entered the Hydra genome through horizontal transfer. Here we provide additional evidence in support of our original hypothesis that the transfer was from a unicellular organism, and we show that the transfer occurred in an ancestor of two medusozoan cnidarian species. In addition we show that the gene is part of a bicistronic operon in the Hydra genome. These findings identify a new animal phylum in which trans-spliced leader addition has led to the formation of operons, and define the requirements for evolution of an operon in Hydra. The identification of operons in Hydra also provides a tool that can be exploited in the construction of transgenic Hydra strains.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.