Trial reportNeurorehabilitation and neural repair
Relating brain damage to brain plasticity in patients with multiple sclerosis.
Trial report in Neurorehabilitation and neural repair. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 3 syntheses or guidelines pooled it, 71 citations in OpenAlex.
- Neuroplasticity and Motor Rehabilitation in Multiple Sclerosis: A Systematic Review on MRI Markers of Functional and Structural Changes.Frontiers in neuroscience · 2021Pooled it
- The Role of fMRI in the Assessment of Neuroplasticity in MS: A Systematic Review.Neural plasticity · 2018Pooled it
- Functional and Structural Brain Plasticity Enhanced by Motor and Cognitive Rehabilitation in Multiple Sclerosis.Neural plasticity · 2015Pooled it
- Effects of motor rehabilitation on mobility and brain plasticity in multiple sclerosis: a structural and functional MRI study.Journal of neurology · 2018Trial
- Robot-supported upper limb training in a virtual learning environment : a pilot randomized controlled trial in persons with MS.Journal of neuroengineering and rehabilitation · 2015Trial
- Adjunctive strategies in multiple sclerosis treatment: non-pharmacological approaches and their potential clinical implications.Journal of translational medicine · 2026Review
- Brain neuroplasticity in multiple sclerosis patients in functional magnetic resonance imaging studies. Part 2: Effect of aerobic training.Polish journal of radiology · 2024Article
- Changes in brain perfusion with training-related visuomotor improvement in MS.Frontiers in molecular neuroscience · 2023Article
- Neurorehabilitation in Multiple Sclerosis-A Review of Present Approaches and Future Considerations.Journal of clinical medicine · 2022Review
- Predictors of training-related improvement in visuomotor performance in patients with multiple sclerosis: A behavioural and MRI study.Multiple sclerosis (Houndmills, Basingstoke, England) · 2021Article
- Altered task-induced cerebral blood flow and oxygen metabolism underlies motor impairment in multiple sclerosis.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021Article
- Open Access: The Effect of Neurorehabilitation on Multiple Sclerosis-Unlocking the Resting-State fMRI Data.Frontiers in neuroscience · 2021Article
- Article
- Influence of RehaCom Therapy on the Improvement of Manual Skills in Multiple Sclerosis Subjects.Annals of rehabilitation medicine · 2020Article
- Can Operant Conditioning of EMG-Evoked Responses Help to Target Corticospinal Plasticity for Improving Motor Function in People With Multiple Sclerosis?Frontiers in neurology · 2020Review
- Synchronization within, and interactions between, the default mode and dorsal attention networks in relapsing-remitting multiple sclerosis.Neuropsychiatric disease and treatment · 2018Article
- How changes in brain activity and connectivity are associated with motor performance in people with MS.NeuroImage. Clinical · 2018Review
- Cognitive Fatigue, Sleep and Cortical Activity in Multiple Sclerosis Disease. A Behavioral, Polysomnographic and Functional Near-Infrared Spectroscopy Investigation.Frontiers in human neuroscience · 2018Article
- Multidisciplinary Rehabilitation is Efficacious and Induces Neural Plasticity in Multiple Sclerosis even when Complicated by Progressive Multifocal Leukoencephalopathy.Frontiers in neurology · 2017Article
- The effect of inflammation and its reduction on brain plasticity in multiple sclerosis: MRI evidence.Human brain mapping · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 5 institutions in 2 countries.
Funding
Abstract
backgroundFailure of adaptive plasticity with increasing pathology is suggested to contribute to progression of disability in multiple sclerosis (MS). However, functional impairments can be reduced with practice, suggesting that brain plasticity is preserved even in patients with substantial damage.
objective. Here, functional magnetic resonance imaging (fMRI) was used to probe systems-level mechanisms of brain plasticity associated with improvements in visuomotor performance in MS patients and related to measures of microstructural damage.
methods23 MS patients and 12 healthy controls underwent brain fMRI during the first practice session of a visuomotor task (short-term practice) and after 2 weeks of daily practice with the same task (longer-term practice). Participants also underwent a structural brain MRI scan.
resultsPatients performed more poorly than controls at baseline. Nonetheless, with practice, patients showed performance improvements similar to controls and independent of the extent of MRI measures of brain pathology. Different relationships between performance improvements and activations were found between groups: greater short-term improvements were associated with lower activation in the sensorimotor, posterior cingulate, and parahippocampal cortices for patients, whereas greater long-term improvements correlated with smaller activation reductions in the visual cortex of controls.
conclusionsBrain plasticity for visuomotor practice is preserved in MS patients despite a high burden of cerebral pathology. Cognitive systems different from those acting in controls contribute to this plasticity in patients. These findings challenge the notion that increasing pathology is accompanied by an outright failure of adaptive plasticity, supporting a neuroscientific rationale for recovery-oriented strategies even in chronically disabled patients.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.