Evidence map›Paper›PMID 22328273›Full record

ReviewDevelopmental neurobiology2012

Behavioral genetics in larval zebrafish: learning from the young.

Marc Wolman, Michael Granato

Abstract readReview
In one paragraph

Review in Developmental neurobiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed.

  1. Surrogate GPR139 Agonists Reverse Short-Term Startle Habituation Impairment in Larval Zebrafish.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Article
  2. Habituation learning: insights from zebrafish larvae.Frontiers in molecular neuroscience · 2025
    Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Gap junction Delta-2b (Frontiers in cell and developmental biology · 2023
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Effects of the Essential Oil fromMolecules (Basel, Switzerland) · 2019
    Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. The Hypocretin/Orexin Neuronal Networks in Zebrafish.Current topics in behavioral neurosciences · 2017
    Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Marc WolmanDepartment of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-6058, USA.
Michael Granato

Funding

Genetic analysis of motor behavior regulationR01MH075691 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI GRANATO, MICHAEL · 2005 to 2009
$1.5M
NIMH NIH HHS R01 MH075691
6 · The paper itself

Abstract

Deciphering the genetic code that determines how the vertebrate nervous system assembles into neural circuits that ultimately control behavior is a fascinating and challenging question in modern neurobiology. Because of the complexity of this problem, successful strategies require a simple yet focused experimental approach without limiting the scope of the discovery. Unbiased, large-scale forward genetic screens in invertebrate organisms have yielded great insight into the genetic regulation of neural circuit assembly and function. For many reasons, this highly successful approach has been difficult to recapitulate in the behavioral neuroscience field's classic vertebrate model organisms-rodents. Here, we discuss how larval zebrafish provide a promising model system to which we can apply the design of invertebrate behavior-based screens to reveal the genetic mechanisms critical for neural circuit assembly and function in vertebrates.

Indexed as

Genetics, BehavioralAge FactorsAnimalsHabituation, PsychophysiologicHumansLarvaLearningReflex, StartleZebrafish

Identifiers

PMID22328273
PMCPMC6430578

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.