ArticleJournal of neurovirology2012
The activity within the CA3 excitatory network during Theiler's virus encephalitis is distinct from that observed during chronic epilepsy.
Article in Journal of neurovirology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 27 citations in OpenAlex.
- Microglia-specific Ido2 deficiency attenuates ictogenesis in the TMEV model of viral encephalitis.Brain, behavior, and immunity · 2025Article
- Establishment of an AI-supported scoring system for neuroglial cells.Frontiers in cellular neuroscience · 2025Article
- Reactive microglia fail to respond to environmental damage signals in a viral-induced mouse model of temporal lobe epilepsy.bioRxiv : the preprint server for biology · 2024Article
- Zika virus infection histories in brain development.Disease models & mechanisms · 2023Review
- Molecular Mechanisms in the Genesis of Seizures and Epilepsy Associated With Viral Infection.Frontiers in molecular neuroscience · 2022Review
- Brain-Derived Neurotrophic Factor Inhibits the Function of Cation-Chloride Cotransporter in a Mouse Model of Viral Infection-Induced Epilepsy.Frontiers in cell and developmental biology · 2022Article
- Inducing sterile pyramidal neuronal death in mice to model distinct aspects of gray matter encephalitis.Acta neuropathologica communications · 2021Article
- Spatially expandable fiber-based probes as a multifunctional deep brain interface.Nature communications · 2020Article
- Ultrastructural and functional changes at the tripartite synapse during epileptogenesis in a model of temporal lobe epilepsy.Experimental neurology · 2020Article
- Viral Triggers and Inflammatory Mechanisms in Pediatric Epilepsy.Molecular neurobiology · 2019Review
- Positive modulation of mGluR5 attenuates seizures and reduces TNF-αExperimental neurology · 2019Article
- Cytotoxic CD8Brain pathology (Zurich, Switzerland) · 2018Article
- Intact interleukin-10 receptor signaling protects from hippocampal damage elicited by experimental neurotropic virus infection of SJL mice.Scientific reports · 2018Article
- Effects of carbamazepine combined with vitamin B12 on levels of plasma homocysteine, hs-CRP and TNF-α in patients with epilepsy.Experimental and therapeutic medicine · 2018Article
- Commonalities in epileptogenic processes from different acute brain insults: Do they translate?Epilepsia · 2018Review
- Neuronal CCL2 expression drives inflammatory monocyte infiltration into the brain during acute virus infection.Journal of neuroinflammation · 2017Article
- NBQX, a highly selective competitive antagonist of AMPA and KA ionotropic glutamate receptors, increases seizures and mortality following picornavirus infection.Experimental neurology · 2016Article
- Decrease in CA3 inhibitory network activity during Theiler's virus encephalitis.Neuroscience letters · 2015Article
- Does brain inflammation mediate pathological outcomes in epilepsy?Advances in experimental medicine and biology · 2014Review
- Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Viral infections of the central nervous system (CNS) are associated with an increased risk for seizures during the acute infection period and the subsequent development of chronic epilepsy that is often difficult to treat. In previous work, we have shown that mice of the C57BL/6 strain infected with Theiler's murine encephalomyelitis virus (TMEV) exhibit a similar sequence, thereby providing a potential useful model of virus-induced epilepsy. The present study examines spontaneous and miniature excitatory postsynaptic currents in CA3 pyramidal cells recorded from brain slices prepared during both the acute phase during encephalitis and 2 months following TMEV infection. Animals that develop chronic epilepsy following TMEV infection exhibit considerable hippocampal sclerosis, directly implicating this brain region in the process of epileptogenesis. There are significant increases in amplitude and frequency of spontaneous and miniature excitatory currents in CA3 cells recorded in brain slices prepared during the acute infection period and 2 months after infection. However, the patterns of changes observed are markedly different during these two periods, suggesting that there are underlying changes in the network over time. These differences have implications for the treatment used during the acute infection and after chronic seizures develop.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.