Trial reportEcoHealth2011
Towards a better understanding of the use of probiotics for preventing chytridiomycosis in Panamanian golden frogs.
Trial report in EcoHealth, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
66 citing papers in PubMed.
- Captive environment induced greater physiological changes than probiotic treatment in Pelophylax nigromaculatus.PloS one · 2026Article
- Microbial responses to antibiotics cryptically shift the direction of disease outcomes.Scientific reports · 2025Article
- Design and regulation of engineered bacteria for environmental release.Nature microbiology · 2025Review
- Skin microbiomes of frogs vary among body regions, revealing differences that reflect known patterns of chytrid infection.Frontiers in microbiology · 2025Article
- The impact of microbiome diversity and composition on host health and susceptibility to disease across amphibian life stages.Frontiers in amphibian and reptile science · 2025Article
- Priority effects alter microbiome composition and increase abundance of probiotic taxa in treefrog tadpoles.Applied and environmental microbiology · 2024Article
- Low-level pathogen infection and geographic location correlate with the skin microbiomes of Columbia spotted frogs (Current research in microbial sciences · 2024Article
- Gene functions of theMicrobial genomics · 2024Article
- Molecular detection ofPeerJ · 2024Article
- Mr. Toad's Wild Fungi: Fungal Isolate Diversity on Colorado Boreal Toads and their Capacity for Pathogen Inhibition.Fungal ecology · 2023Article
- Immune priming prior to pathogen exposure sheds light on the relationship between host, microbiome and pathogen in disease.Royal Society open science · 2023Article
- Host ecology drives frog skin microbiome diversity across ecotone in South-Central North America.Frontiers in microbiomes · 2023Article
- When Defenses Fail: Atelopus zeteki Skin Secretions Increase Growth of the Pathogen Batrachochytrium dendrobatidis.Integrative and comparative biology · 2022Article
- Body condition, skin bacterial communities and disease status: insights from the first release trial of the limosa harlequin frog,Proceedings. Biological sciences · 2022Article
- Microbial Diversity of the Chinese Tiger Frog (Animals : an open access journal from MDPI · 2022Article
- A review of chemical defense in harlequin toads (Bufonidae:Toxicon: X · 2022Review
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- Exploring the Diversity and Biotechnological Potential of Cultured and Uncultured Coral-Associated Bacteria.Microorganisms · 2021Article
- Genetically modifying skin microbe to produce violacein and augmenting microbiome did not defend Panamanian golden frogs from disease.ISME communications · 2021Article
6 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Populations of native Panamanian golden frogs (Atelopus zeteki) have collapsed due to a recent chytridiomycosis epidemic. Reintroduction efforts from captive assurance colonies are unlikely to be successful without the development of methods to control chytridiomycosis in the wild. In an effort to develop a protective treatment regimen, we treated golden frogs with Janthinobacterium lividum, a skin bacterium that has been used to experimentally prevent chytridiomycosis in North American amphibians. Although J. lividum appeared to colonize A. zeteki skin temporarily, it did not prevent or delay mortality in A. zeteki exposed to Batrachochytrium dendrobatidis, the causative agent of chytridiomycosis. After introduction of J. lividum, average bacterial cell counts reached a peak of 1.7 × 10(6) cells per frog ~2 weeks after treatment but declined steadily after that. When J. lividum numbers declined to ~2.8 × 10(5) cells per frog, B. dendrobatidis infection intensity increased to greater than 13,000 zoospore equivalents per frog. At this point, frogs began to die of chytridiomycosis. Future research will concentrate on isolating and testing antifungal bacterial species from Panama that may be more compatible with Atelopus skin.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.