SynthesisCurrent neurology and neuroscience reports2012
REM sleep behavior disorder and REM sleep without atonia as an early manifestation of degenerative neurological disease.
Synthesis in Current neurology and neuroscience reports, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 53 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
53 citing papers in PubMed, 1 synthesis or guideline pooled it, 132 citations in OpenAlex.
- Technologies for Monitoring Lifestyle Habits Related to Brain Health: A Systematic Review.Sensors (Basel, Switzerland) · 2019Pooled it
- Sleep impairments in refugees diagnosed with post-traumatic stress disorder: a polysomnographic and self-report study.European journal of psychotraumatology · 2023Trial
- Predictors of dream enactment behavior among medical students: The case of the University of Gondar, Ethiopia.PloS one · 2022Trial
- Effect of TAAR1/5-HTTranslational psychiatry · 2021Trial
- Accelerated Progression of Gait Impairment in Parkinson's Disease and REM Sleep Without Atonia.Annals of clinical and translational neurology · 2026Article
- Prevalence and Impact of Probable REM Sleep Behavior Disorder in Essential Tremor: A Multicenter Cross-Sectional Study.European journal of neurology · 2026Article
- Continuous sleep depth index annotation with deep learning yields novel digital biomarkers for sleep health.NPJ digital medicine · 2025Article
- Ictal SPECT Imaging Findings in Parkinson's Disease with Rapid Eye Movement Sleep Behavior Disorder.Movement disorders clinical practice · 2025Article
- MRI brain structural and functional networks changes in Parkinson disease with REM sleep behavior disorders.Frontiers in aging neuroscience · 2024Article
- The Genetic Basis of Probable REM Sleep Behavior Disorder in Parkinson's Disease.Brain sciences · 2023Article
- Magnetic susceptibility changes in the brainstem reflect REM sleep without atonia severity in isolated REM sleep behavior disorder.NPJ Parkinson's disease · 2023Article
- Common Sleep Disorders Affecting Older Adults.The Permanente journal · 2023Review
- Cardiac Autonomic Dysfunction Is Associated with Severity of REM Sleep without Atonia in Isolated REM Sleep Behavior Disorder.Journal of clinical medicine · 2021Article
- Sleep Disturbances and Phenoconversion in Patients with REM Sleep Behavior Disorder.Journal of clinical medicine · 2021Article
- Timeline of Rapid Eye Movement Sleep Behavior Disorder in Overt Alpha-Synucleinopathies.Annals of neurology · 2021Article
- Gastric Electrical Dysarrhythmia in Probable Rapid Eye Movement Sleep Behavior Disorder.Frontiers in neurology · 2021Article
- Quantitative REM Sleep without Atonia in Parkinson's Disease and Essential Tremor.Movement disorders clinical practice · 2021Article
- Rapid Eye Movement Sleep Behavior Disorder and Neurodegenerative Diseases: An Update.Aging and disease · 2020Review
- Article
- Prognostic Counseling for Patients With Idiopathic/Isolated REM Sleep Behavior Disorder: Should We Tell Them What's Coming? Yes.Movement disorders clinical practice · 2019Article
Corrections and comments
- Erratum issued
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Rapid eye movement (REM) sleep behavior disorder (RBD) is a parasomnia characterized by repeated episodes of dream enactment behavior and REM sleep without atonia (RSWA) during polysomnography recording. RSWA is characterized by increased phasic or tonic muscle activity seen on polysomnographic electromyogram channels. RSWA is a requisite diagnostic feature of RBD, but may also be seen in patients without clinical symptoms or signs of dream enactment as an incidental finding in neurologically normal individuals, especially in patients receiving antidepressant therapy. RBD may be idiopathic or symptomatic. Patients with idiopathic RBD often later develop other neurological features including parkinsonism, orthostatic hypotension, anosmia, or cognitive impairment. RSWA without clinical symptoms as well as clinically overt RBD also often occurs concomitantly with the α-synucleinopathy family of neurodegenerative disorders, which includes idiopathic Parkinson disease, Lewy body dementia, and multiple system atrophy. This review article considers the epidemiology of RBD, clinical and polysomnographic diagnostic standards for both RBD and RSWA, previously reported associations of RSWA and RBD with neurodegenerative disorders and other potential causes, the pathophysiology of which brain structures and networks mediate dysregulation of REM sleep muscle atonia, and considerations for the effective and safe management of RBD.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.