ReviewCurrent hypertension reports2012
Vitamin D and vascular disease: the current and future status of vitamin D therapy in hypertension and kidney disease.
Review in Current hypertension reports, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 40 citations in OpenAlex.
- Effects of curcumin supplementation on vitamin D levels in women with premenstrual syndrome and dysmenorrhea: a randomized controlled study.BMC complementary medicine and therapies · 2022Trial
- Effect of vitamin D supplementation versus placebo on essential hypertension in patients with vitamin D deficiency: a double-blind randomized clinical trial.Journal of clinical hypertension (Greenwich, Conn.) · 2020Trial
- Trial
- Association between vitamin D deficiency and adrenal gland, kidney function, indicators related to cardiovascular function in hypertensive patients.Frontiers in nutrition · 2026Article
- Fok I and Bsm I gene polymorphism of vitamin D receptor and essential hypertension: a mechanistic link.Clinical hypertension · 2023Review
- Vitamin D status of overweight and obese Bangladeshi adults.Journal of family medicine and primary care · 2020Article
- A systematic review of the role of vitamin D and calcium in premenstrual syndrome.Obstetrics & gynecology science · 2019Review
- The effects of vitamin D supplementation on endothelial activation among patients with metabolic syndrome and related disorders: a systematic review and meta-analysis of randomized controlled trials.Nutrition & metabolism · 2018Review
- The Use of 1α,25-Dihydroxyvitamin D₃ as an Anticancer Agent.International journal of molecular sciences · 2016Review
- Nutraceuticals and Blood Pressure Control: Results from Clinical Trials and Meta-Analyses.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2015Review
- The renin-angiotensin-aldosterone system and calcium-regulatory hormones.Journal of human hypertension · 2015Review
- Observational multicenter study to evaluate the prevalence and prognosis of subclinical atheromatosis in a Spanish chronic kidney disease cohort: baseline data from the NEFRONA study.BMC nephrology · 2014Observational
- Interactions between adrenal-regulatory and calcium-regulatory hormones in human health.Current opinion in endocrinology, diabetes, and obesity · 2014Review
- Plasma 25-hydroxyvitamin D and risk of premenstrual syndrome in a prospective cohort study.BMC women's health · 2014Article
- Evaluating hormonal mechanisms of vitamin D receptor agonist therapy in diabetic kidney disease: the VALIDATE-D study.BMC endocrine disorders · 2013Article
- Evidence of clinically relevant efficacy for dietary supplements and nutraceuticals.Current hypertension reports · 2013Review
- Low 25-hydroxyvitamin D levels and cognitive impairment in hemodialysis patients.Clinical journal of the American Society of Nephrology : CJASN · 2013Article
- The influence of sodium- and calcium-regulatory hormone interventions on adipocytokines in obesity and diabetes.Metabolism: clinical and experimental · 2013Article
- The problems of vitamin d insufficiency in older people.Aging and disease · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Over the past decade, vitamin D has generated considerable interest as potentially having important effects on the vasculature and the kidney. Animal and human data indicate that vitamin D suppresses the activity of the renin-angiotensin system and improves endothelial function. Observational studies in humans suggest that low 25-hydroxyvitamin D (25[OH]D) levels are associated with a higher risk of hypertension. However, findings from randomized trials of vitamin D supplementation (with cholecalciferol or ergocalciferol) to lower blood pressure are inconsistent, possibly stemming from variability in study population, sample size, vitamin D dose, and duration. Supplementation with activated vitamin D (i.e., 1,25-dihydroxyvitamin D or analogues) in patients with chronic kidney disease reduces urine albumin excretion, an important biomarker for future decline in renal function. These studies are reviewed, with special emphasis on recent findings. Definitive studies are warranted to elucidate the effects of vitamin D supplementation on mechanisms of hypertension and kidney disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.