ArticleBrain imaging and behavior2012
Functional connectivity measured with magnetoencephalography identifies persons with HIV disease.
Article in Brain imaging and behavior, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Functional brain abnormalities during finger-tapping in HIV-infected older adults: a magnetoencephalography study.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2013Trial
- Characteristics of cortical thickness in treated HIV-infected individuals with and without cognitive impairment.European journal of medical research · 2025Article
- People with HIV exhibit spectrally distinct patterns of rhythmic cortical activity serving cognitive flexibility.Neurobiology of disease · 2024Article
- Biotypes of Central Nervous System Complications in People Living With Human Immunodeficiency Virus (HIV): National Institute of Mental Health Perspectives on Advancing the Future of HIV Healthcare.The Journal of infectious diseases · 2023Article
- Gray matter volumes discriminate cognitively impaired and unimpaired people with HIV.NeuroImage. Clinical · 2021Article
- Brain structural correlates of trajectories to cognitive impairment in men with and without HIV disease.Brain imaging and behavior · 2020Article
- Interactive effects of HIV and ageing on neural oscillations: independence from neuropsychological performance.Brain communications · 2020Article
- Frequency and Correlates of Subjective Cognitive Impairment in HIV Disease.AIDS and behavior · 2019Article
- Aberrant brain dynamics in neuroHIV: Evidence from magnetoencephalographic (MEG) imaging.Progress in molecular biology and translational science · 2019Review
- Neural dynamics of selective attention deficits in HIV-associated neurocognitive disorder.Neurology · 2018Article
- Aberrant occipital dynamics differentiate HIV-infected patients with and without cognitive impairment.Brain : a journal of neurology · 2018Article
- Frequency-based brain networks: From a multiplex framework to a full multilayer description.Network neuroscience (Cambridge, Mass.) · 2018Article
- Neuroimaging with magnetoencephalography: A dynamic view of brain pathophysiology.Translational research : the journal of laboratory and clinical medicine · 2016Review
- Cortical brain atrophy and intra-individual variability in neuropsychological test performance in HIV disease.Brain imaging and behavior · 2016Article
- Characteristics of Resting-State Functional Connectivity in HIV-Associated Neurocognitive Disorder.PloS one · 2016Article
- Multimodal neuroimaging evidence of alterations in cortical structure and function in HIV-infected older adults.Human brain mapping · 2015Article
- HIV infection is associated with attenuated frontostriatal intrinsic connectivity: a preliminary study.Journal of the International Neuropsychological Society : JINS · 2015Article
- HIV effects on age-associated neurocognitive dysfunction: premature cognitive aging or neurodegenerative disease?Alzheimer's research & therapy · 2015Article
- Determinants of HIV-induced brain changes in three different periods of the early clinical course: A data mining analysis.NeuroImage. Clinical · 2015Article
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Authors and funding
11 authors.
Funding
Abstract
There is need for a valid and reliable biomarker for HIV Associated Neurocognitive Disorder (HAND). The purpose of the present study was to provide preliminary evidence of the potential utility of neuronal functional connectivity measures obtained using magnetoencephalography (MEG) to identify HIV-associated changes in brain function. Resting state, eyes closed, MEG data from 10 HIV-infected individuals and 8 seronegative controls were analyzed using mutual information (MI) between all pairs of MEG sensors to determine whether there were functional brain networks that distinguished between subject groups based on cognition (global and learning) or on serostatus. Three networks were identified across all subjects, but after permutation testing (at α < .005) only the one related to HIV serostatus was significant. The network included MEG sensors (planar gradiometers) above the right anterior region connecting to sensors above the left posterior region. A mean MI value was calculated across all connections from the anterior to the posterior groupings; that score distinguished between the serostatus groups with only one error (sensitivity = 1.00, specificity = .88 (X ( 2 ) = 15.4, df = 1, p < .01, Relative Risk = .11). There were no significant associations between the MI value and the neuropsychological Global Impairment Rating, substance abuse, mood disorder, age, education, CD4+ cell counts or HIV viral load. We conclude that using a measure of functional connectivity, it may be possible to distinguish between HIV-infected and uninfected individuals, suggesting that MEG may have the potential to serve as a sensitive, non-invasive biomarker for HAND.
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