ArticleHistochemistry and cell biology2012
Redistribution of adhering junctions in human endometrial epithelial cells during the implantation window of the menstrual cycle.
Article in Histochemistry and cell biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 52 citations in OpenAlex.
- Alternative splicing and differential gene expression during changes in endometrial receptivity in patients with recurrent implantation failure.Scientific reports · 2026Article
- The Role of Biomechanical Regulation in Physiological and Pathological Pregnancy: From Mechanotransduction to Clinical Implications.International journal of biological sciences · 2026Review
- The effect of Hydrocortisone on implantation through upregulation of tight junction genes: A lab trial study.JBRA assisted reproduction · 2025Article
- Changes in Epithelial Cell Polarity and Adhesion Guide Human Endometrial Receptivity: How In Vitro Systems Help to Untangle Mechanistic Details.Biomolecules · 2025Review
- Bioprinted Hormone-Responsive Bilayer Model of Human Endometrium for Embryo Implantation Studies.ACS biomaterials science & engineering · 2025Article
- Cell Communication in Endometrium: Understanding and Improving Endometrial Biomarkers.Advances in experimental medicine and biology · 2025Review
- Microbial metabolites short chain fatty acids, tight junction, gap junction, and reproduction: a review.Frontiers in cell and developmental biology · 2025Review
- Article
- An Assessment of the Mechanophysical and Hormonal Impact on Human Endometrial Epithelium Mechanics and Receptivity.International journal of molecular sciences · 2024Article
- The immunolocalization of cadherins and beta-catenin in the cervix and vagina of cycling cows.Veterinary research communications · 2023Article
- microRNA-based signatures obtained from endometrial fluid identify implantative endometrium.Human reproduction (Oxford, England) · 2022Article
- Review
- In focus in HCB.Histochemistry and cell biology · 2021Article
- Steroid hormones and human choriogonadotropin influence the distribution of alpha6-integrin and desmoplakin 1 in gland-like endometrial epithelial spheroids.Histochemistry and cell biology · 2021Article
- Potential Marker Pathways in the Endometrium That May Cause Recurrent Implantation Failure.Reproductive sciences (Thousand Oaks, Calif.) · 2019Article
- Article
- A fast screening model for drug permeability assessment based on native small intestinal extracellular matrix.RSC advances · 2018Article
- Direct Cell⁻Cell Interactions in the Endometrium and in Endometrial Pathophysiology.International journal of molecular sciences · 2018Review
- Epithelial cadherin disassociates from the lateral plasma membrane of uterine epithelial cells throughout pregnancy in a marsupial.Journal of anatomy · 2017Article
- Endometrial Stromal Decidualization Responds Reversibly to Hormone Stimulation and Withdrawal.Endocrinology · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The human uterine epithelium is characterised by remarkable plasticity with cyclic changes in differentiation that are controlled by ovarian steroid hormones to optimise conditions for embryo implantation. To understand whether and how cell-cell adhesion is affected, the localisation of junction proteins was studied throughout the menstrual cycle. Expression patterns were examined by immunofluorescence in 36 human endometrial specimens of different cycle stages. Antibodies against the desmosomal proteins desmoplakin 1/2 (Dp 1/2) and desmoglein 2 (Dsg 2), the adherens junction proteins E-cadherin and β-catenin and also the common junctional linker protein plakoglobin showed a strong subapical staining during the proliferative phase until the early luteal phase (day 20). In the mid- to late luteal phase, however, these junctional proteins redistributed over the entire lateral plasma membranes. In contrast, tight junction proteins (ZO-1, claudin 4) remained at their characteristic subapical position throughout the menstrual cycle. mRNA levels of Dp 1/2, E-cadherin and ZO-1 obtained by real time RT-PCR were not significantly changed during the menstrual cycle. The observed redistribution of desmosomes and adherens junctions coincides with the onset of the so called implantation window of human endometrium. We propose that this change is controlled by ovarian steroids and prepares the endometrium for successful trophoblast invasion.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.