ArticleHistochemistry and cell biology2012
Thy-1-positive cells in the subodontoblastic layer possess high potential to differentiate into hard tissue-forming cells.
Article in Histochemistry and cell biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Odontoblasts in Equine Hypsodont Teeth-How They Cope with Permanent Occlusal Wear.Animals : an open access journal from MDPI · 2026Article
- In vivo dynamics of hard tissue-forming cell origins: Insights from Cre/loxP-based cell lineage tracing studies.The Japanese dental science review · 2024Review
- Polycomb protein Bmi1 promotes odontoblast differentiation by accelerating Wnt and BMP signaling pathways.Histochemistry and cell biology · 2024Article
- Localization of Both CD31- and Endomucin-Expressing Vessels in Mouse Dental Pulp.Acta histochemica et cytochemica · 2024Article
- Isolation and cultivation as well asFrontiers in veterinary science · 2023Article
- Therapeutic potential of dental pulp stem cells and their derivatives: Insights from basic research toward clinical applications.World journal of stem cells · 2022Review
- Comparison of gingiva-derived and bone marrow mesenchymal stem cells for osteogenesis.Journal of cellular and molecular medicine · 2019Article
- Changes of CD90 expression and immunoreactive cell localisation in rat dental pulp after cavity preparation.Australian endodontic journal : the journal of the Australian Society of Endodontology Inc · 2019Article
- Thy1 is a positive regulator of osteoblast differentiation and modulates bone homeostasis in obese mice.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2018Article
- Thy-1 Deficiency Augments Bone Loss in Obesity by Affecting Bone Formation and Resorption.Frontiers in cell and developmental biology · 2018Article
- Isolation of dental pulp stem cells with high osteogenic potential.Inflammation and regeneration · 2017Review
- Differentiation potential of rabbit CD90-positive cells sorted from adipose-derived stem cells in vitro.In vitro cellular & developmental biology. Animal · 2017Article
- Osteogenic Potential of Mouse Periosteum-Derived Cells Sorted for CD90 In Vitro and In Vivo.Stem cells translational medicine · 2016Article
- Mesenchymal Stem Cells Subpopulations: Application for Orthopedic Regenerative Medicine.Stem cells international · 2016Review
- Positive selection for bone morphogenetic protein receptor type-IB promotes differentiation and specification of human adipose-derived stromal cells toward an osteogenic lineage.Tissue engineering. Part A · 2014Article
- Localization of SUMOylation factors and Osterix in odontoblast lineage cells during dentin formation and regeneration.Histochemistry and cell biology · 2013Article
- The Histochemistry and Cell Biology compendium: a review of 2012.Histochemistry and cell biology · 2013Review
- CD90 (Thy-1)-positive selection enhances osteogenic capacity of human adipose-derived stromal cells.Tissue engineering. Part A · 2013Article
- Two distinct processes of bone-like tissue formation by dental pulp cells after tooth transplantation.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2012Article
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Authors and funding
9 authors.
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Abstract
The cells of the subodontoblastic cell-rich layer in dental pulp are speculated to contain odontoblast progenitor cells because of their positional relationship with odontoblasts as well as their high alkaline phosphatase (ALP) activity. However, it has yet to be determined whether these cells have the ability to differentiate into odontoblastic cells. In the present study, we firstly found that the majority of cells in the subodontoblastic layer expressed Thy-1, a cell-surface marker of stem and progenitor cells. Then, we evaluated the capacity of Thy-1 high- and low-expressing (Thy-1(high) and Thy-1(low)) cells separated from rat dental pulp cells by use of a fluorescence-activated cell sorter to differentiate into hard tissue-forming cells in vitro and in vivo. Following stimulation with bone morphogenetic protein-2, Thy-1(high) cells in vitro showed accelerated induction of ALP activity and formation of alizarin red-positive mineralized matrix compared with Thy-1(low) cells. Furthermore, subcutaneous implantation of Thy-1(high) cells efficiently induced the formation of bone-like matrix. These results collectively suggest that Thy-1-positive dental pulp cells localized in the subodontoblastic layer had the ability to differentiate into hard tissue-forming cells, and thus these cells may serve as a source of odontoblastic cells.
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