ArticleHistochemistry and cell biology2012
Human periodontal ligament fibroblasts are the optimal cell source for induced pluripotent stem cells.
Article in Histochemistry and cell biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Single-Cell Transcriptomics Reveal Microenvironment Alterations in Canine Peri-Implantitis.Mediators of inflammation · 2025Article
- Mechanisms involved in regulation of periodontal ligament cell production of pro-inflammatory cytokines: Implications in periodontitis.Journal of periodontal research · 2021Review
- Although Anatomically Micrometers Apart: Human Periodontal Ligament Cells Are Slightly More Active in Bone Remodeling Than Alveolar Bone Derived Cells.Frontiers in cell and developmental biology · 2021Article
- Article
- Induced Pluripotent Stem Cells in Dental and Nondental Tissue Regeneration: A Review of an Unexploited Potential.Stem cells international · 2020Review
- Luteolin supports osteogenic differentiation of human periodontal ligament cells.BMC oral health · 2019Article
- Strategies to Optimize Adult Stem Cell Therapy for Tissue Regeneration.International journal of molecular sciences · 2016Review
- GGsTOP increases migration of human periodontal ligament cells in vitro via reactive oxygen species pathway.Molecular medicine reports · 2016Article
- Mechanoresponsive Properties of the Periodontal Ligament.Journal of dental research · 2016Article
- Cementogenic potential of multipotential mesenchymal stem cells purified from the human periodontal ligament.Odontology · 2015Article
- Adhesion and proliferation of human periodontal ligament cells on poly(2-methoxyethyl acrylate).BioMed research international · 2014Article
- Article
- The Histochemistry and Cell Biology compendium: a review of 2012.Histochemistry and cell biology · 2013Review
- Induced Pluripotent Stem Cells and Periodontal Regeneration.Current oral health reportsReview
- The diverse role of oral fibroblasts in normal and disease.Journal of oral and maxillofacial pathology : JOMFPReview
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Among the various kinds of fibroblasts existing in the human body, the periodontal ligament (PDL) fibroblasts have been suggested as multipotent cells. Periodontal ligament fibroblasts are characterized by rapid turnover, a high remodeling capacity and remarkable capacity for renewal and repair. They also differentiate into osteoblasts and cementoblasts. We established iPS cells from human PDL fibroblasts by introducing the ES cell markers Oct3/4, Sox2, Nanog, Klf4 and Lin28 by retrovirus transduction, even without the oncogene c-Myc. The iPS cells established in this study expressed the ES cell markers and formed teratomas in SCID mice. The c-Myc expression level in the PDL fibroblasts was higher than that in the iPS cells by quantitative RT-PCR. Therefore, we have concluded that PDL fibroblasts could be an optimal cell source for iPS cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.