ArticleMolecular biology reports2012
Genetic variations in immunoglobulin G3 and association with staphylococcal intra-mammary infections in cattle and buffaloes.
Article in Molecular biology reports, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 3 citations in OpenAlex.
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Animals (n = 152) suffering with mastitis were used to study association between immunoglobulin G3 (IgG3) genotypes and staphylococcal mastitis. Thus, animals (affected and unaffected) were evaluated using PCR-RFLP. Restriction digestion of amplicons of IgG3 using BstYI showed allele A and, genotypes AC, AB and AA predominated in Karan Fries, Sahiwal and Murrah, respectively. HphI digestion revealed allele A and, genotypes AC and AB in higher frequency in animals of first group of all the breeds. Additionally, genotypes associated with mastitic infection showed predominance of AB (BstYI) in unaffected animals of Sahiwal and Murrah; whereas AC and AA were observed in affected group only. Genotype AB (HphI) was prevalent in unaffected and AC in affected animals of Karan Fries and Sahiwal. In Murrah, AC was common in affected and unaffected animal; while AB remained in affected category. Identified genotypes associated with determinants of SpA gene of S. aureus strains revealed the significant outcome. For example AB (BstYI) was found to be correalted with SpA ≤ 7R; whereas with SpA > 7R in Karan Fries. Genotypes AA and AB were more favorably associated with SpA ≤ 7R and AB with the SpA > 7R in Sahiwal cattle. The genotype AB seemed influenced (100%) with SpA > 7R and AC in SpA ≤ 7R in cases of Murrah. Similarly, AA (HphI) in Karan Fries was more likely to be correlated with SpA ≤ 7R, while AC with SpA > 7R. Overall, the molecular analysis revealed that IgG3 gene could be use for selection of animals against mastitis. However, further investigations on IgG3 needed to aid in identify disease- resistant animal.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.