ArticleMolecular biology reports2012
BRCA1: a new candidate gene for bovine mastitis and its association analysis between single nucleotide polymorphisms and milk somatic cell score.
Article in Molecular biology reports, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.
- Pooled it
- Article
- Mammalian Species-Specific Resistance to Mammary Cancer.Journal of mammary gland biology and neoplasia · 2025Review
- Explainable coronary artery disease prediction model based on AutoGluon from AutoML framework.Frontiers in cardiovascular medicine · 2024Article
- Genetic polymorphisms in immune- and inflammation-associated genes and their association with bovine mastitis resistance/susceptibility.Frontiers in immunology · 2023Review
- Candidate Genes and Their Expressions Involved in the Regulation of Milk and Meat Production and Quality in Goats (Animals : an open access journal from MDPI · 2022Review
- Bovine mastitis prevention and control in the post-antibiotic era.Tropical animal health and production · 2021Review
- Genome-wide association study of milk and reproductive traits in dual-purpose Xinjiang Brown cattle.BMC genomics · 2019Article
- Prioritizing candidate genes post-GWAS using multiple sources of data for mastitis resistance in dairy cattle.BMC genomics · 2018Article
- Molecular biological tools applied for identification of mastitis causing pathogens.International journal of veterinary science and medicine · 2017Review
- Article
- Molecular markers for resistance against infectious diseases of economic importance.Veterinary world · 2017Review
- Molecular characterization and combined genotype association study of bovine cluster of differentiation 14 gene with clinical mastitis in crossbred dairy cattle.Veterinary world · 2016Article
- DNA Barcoding Evaluation and Its Taxonomic Implications in the Recently Evolved GenusFrontiers in plant science · 2016Article
- Genome-wide association study in Chinese Holstein cows reveal two candidate genes for somatic cell score as an indicator for mastitis susceptibility.BMC genetics · 2015Article
- Association analyses of FGFR2 gene polymorphisms with femoral neck bone mineral density in Chinese Han population.Molecular genetics and genomics : MGG · 2015Article
- Haplotype analysis of TLR4 gene and its effects on milk somatic cell score in Chinese commercial cattle.Molecular biology reports · 2014Article
- Association analyses of osteoprotegerin gene polymorphisms with bone mineral density in Chinese postmenopausal women.Medical oncology (Northwood, London, England) · 2013Article
- Chronobiology in mammalian health.Molecular biology reports · 2013Review
- HRAS: a webserver for early warning of human health risk brought by aflatoxin.Molecular biology reports · 2013Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bovine mastitis is a very complex and common disease of dairy cattle and a major source of economic losses to the dairy industry worldwide. In this study, the bovine breast cancer 1, early onset gene (BRCA1) was taken as a candidate gene for mastitis resistance. The main object of this study was to investigate whether the BRCA1 gene was associated with mastitis in cattle. Through DNA sequencing, Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) and Created Restriction Site PCR (CRS-PCR) methods, three SNPs (G22231T, T25025A, and C28300A) were detected and twenty-four combinations of these SNPs were observed. The single SNP and their genetic effects on somatic cell score (SCS) were evaluated and a significant association with SCS was found in C28300A. The mean of genotype EE was significantly lower than those of genotypes EF and FF. The results of combined genotypes analysis of three SNPs showed that BBDDFF genotype with the highest SCS were easily for the mastitis susceptibility, whereas AACCEE genotype with the lowest SCS were favorable for the mastitis resistance. The information provided in the present study will be very useful for improving mastitis resistance in dairy cattle by marker-assisted selection.
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