ArticleThe Plant cell2012
EARLY FLOWERING4 recruitment of EARLY FLOWERING3 in the nucleus sustains the Arabidopsis circadian clock.
Article in The Plant cell, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 163 papers.
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Who cites it
163 citing papers in PubMed, 322 citations in OpenAlex.
- Nuclear basket localized proteasomes maintain circadian period through nuclear TOC1 proteolysis.bioRxiv : the preprint server for biology · 2026Article
- Sensing and Filtering Environmental Fluctuations: The Case of Biomolecular Condensates in Plants.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- The circadian clock of Populus affects physiological, transcriptional and metabolomic responses to osmotic and ionic components of salt stress.Npj biological timing and sleep · 2025Article
- Early Flowering 3 (ELF3) Inhibits Hypocotyl Phototropism in Light-GrownPlant direct · 2025Article
- Ambient temperature influenced co-expression network of major developmental, circadian, and photoreceptor genes in bread wheat.Scientific reports · 2025Article
- Simple sequence repeats and their expansions: role in plant development, environmental response and adaptation.The New phytologist · 2025Review
- Review
- Stable and dynamic gene expression patterns over diurnal and developmental timescales in Arabidopsis thaliana.The New phytologist · 2025Article
- Molecular genetic regulation of the vegetative-generative transition in wheat from an environmental perspective.Annals of botany · 2025Review
- Circadian clock regulation in soybean senescence: a transcriptome analysis of early and late senescence types.BMC genomics · 2025Article
- Research progress on delayed flowering under short-day condition inFrontiers in plant science · 2025Review
- The evening complex component ELF3 recruits H3K4me3 demethylases to repress PHYTOCHROME INTERACTING FACTOR4 and 5 in Arabidopsis.The Plant cell · 2024Article
- Dual roles of pear EARLY FLOWERING 4 -like genes in regulating flowering and leaf senescence.BMC plant biology · 2024Article
- An Arabidopsis Cell Culture With Weak Circadian Rhythms Under Constant Light Compared With Constant Dark Can Be Rescued by ELF3.Plant direct · 2024Article
- Tracing the Evolutionary History of the Temperature-Sensing Prion-like Domain in EARLY FLOWERING 3 Highlights the Uniqueness of AtELF3.Molecular biology and evolution · 2024Article
- Inferring upstream regulatory genes of FOXP3 in human regulatory T cells from time-series transcriptomic data.NPJ systems biology and applications · 2024Article
- Investigating the genetic control of plant development in spring barley under speed breeding conditions.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2024Article
- Complex epistatic interactions between ELF3, PRR9, and PRR7 regulate the circadian clock and plant physiology.Genetics · 2024Article
- Unlocking allelic variation in circadian clock genes to develop environmentally robust and productive crops.Planta · 2024Review
- Epigenetic variation in early and late flowering plants of the rubber-producing Russian dandelion Taraxacum koksaghyz provides insights into the regulation of flowering time.Scientific reports · 2024Article
103 more citing papers are in PubMed but not listed here.
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Authors and funding
13 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The plant circadian clock is proposed to be a network of several interconnected feedback loops, and loss of any component leads to changes in oscillator speed. We previously reported that Arabidopsis thaliana EARLY FLOWERING4 (ELF4) is required to sustain this oscillator and that the elf4 mutant is arrhythmic. This phenotype is shared with both elf3 and lux. Here, we show that overexpression of either ELF3 or LUX ARRHYTHMO (LUX) complements the elf4 mutant phenotype. Furthermore, ELF4 causes ELF3 to form foci in the nucleus. We used expression data to direct a mathematical position of ELF3 in the clock network. This revealed direct effects on the morning clock gene PRR9, and we determined association of ELF3 to a conserved region of the PRR9 promoter. A cis-element in this region was suggestive of ELF3 recruitment by the transcription factor LUX, consistent with both ELF3 and LUX acting genetically downstream of ELF4. Taken together, using integrated approaches, we identified ELF4/ELF3 together with LUX to be pivotal for sustenance of plant circadian rhythms.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.