SynthesisCurrent opinion in obstetrics & gynecology2012
Vitamin D in pregnancy: current concepts.
Synthesis in Current opinion in obstetrics & gynecology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02920593 (A Randomized Control Trial of Vitamin D Prophylaxis in the Prevention of Hypertensive Disorders of Pregnancy), which is not on this map. Cited by 42 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Randomized Control Trial of Vitamin D Prophylaxis in the Prevention of Hypertensive Disorders of Pregnancy
Who cites it
42 citing papers in PubMed, 1 synthesis or guideline pooled it, 100 citations in OpenAlex.
- Maternal and cord blood vitamin D status and childhood infection and allergic disease: a systematic review.Nutrition reviews · 2016Pooled it
- Low maternal vitamin D status during the second trimester of pregnancy: a cross-sectional study in Wuxi, China.PloS one · 2015Trial
- Vitamin D and calcium status in preeclampsia and pregnancy-induced hypertension.Biomolecules & biomedicine · 2025Observational
- Article
- The Correlation between Maternal and Neonatal Vit D (25(OH)D) Levels in Greece: A Cross-Sectional Study.Clinics and practice · 2024Article
- Article
- Influence of Strict Lockdown on Vitamin D Deficiency in Pregnant Women: A Word of Caution.Nutrients · 2023Article
- Association between vitamin D level in mother's serum and the level of vitamin D in the serum of pre-term infants.BMC pediatrics · 2023Article
- Article
- Immunonutrients involved in the regulation of the inflammatory and oxidative processes: implication for gamete competence.Journal of assisted reproduction and genetics · 2022Review
- Vitamin D Deficiency and Gestational Diabetes Mellitus in Relation to Body Mass Index.Nutrients · 2021Observational
- Recommendations on the measurement and the clinical use of vitamin D metabolites and vitamin D binding protein - A position paper from the IFCC Committee on bone metabolism.Clinica chimica acta; international journal of clinical chemistry · 2021Review
- Maternal Vitamin D Levels During Pregnancy in Association With Autism Spectrum Disorders (ASD) or Intellectual Disability (ID) in Offspring; Exploring Non-linear Patterns and Demographic Sub-groups.Autism research : official journal of the International Society for Autism Research · 2020Article
- Article
- Brief Report: Markers of Spontaneous Preterm Delivery in Women Living With HIV: Relationship With Protease Inhibitors and Vitamin D.Journal of acquired immune deficiency syndromes (1999) · 2019Article
- Newborn vitamin D levels in relation to autism spectrum disorders and intellectual disability: A case-control study in california.Autism research : official journal of the International Society for Autism Research · 2019Article
- Serum Levels of Asymmetric and Symmetric Dimethylarginine in Women with Vitamin D Deficiency and History of Pregnancy Loss - A Pilot Study.Journal of medical biochemistry · 2018Article
- Vitamin D levels in an Australian and New Zealand cohort and the association with pregnancy outcome.BMC pregnancy and childbirth · 2018Article
- Maternal vitamin D supplementation during pregnancy.British medical bulletin · 2018Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
purpose of reviewVitamin D is part of a complex steroid hormone system long known to be involved in bone metabolism. Recently, vitamin D has been implicated in physiologic processes as diverse as vascular health, immune function, metabolism and placental function. This review summarizes the current evidence for the role of vitamin D in pregnancy and perinatal outcomes A systematic review of articles published in PubMed between May 2010 and October 2011 was undertaken using key words for vitamin D and pregnancy. Seventy-eight studies were reviewed. RECENT
findingsThe biologic evidence regarding a role for vitamin D in reproductive outcomes is strong, and rates of vitamin D deficiency may be high among pregnant women. However, no consensus exists regarding optimum vitamin D levels in pregnancy or standard measurement of vitamin D deficiency. Clinical studies establishing an association between vitamin D levels and adverse pregnancy outcomes such as preeclampsia, gestational diabetes, low birthweight, preterm labor, cesarean delivery and infectious diseases have conflicting results. This is likely due to a paucity of randomized trials, heterogeneity of populations studied and low sample size with poor adjustment for confounding among observational studies. SUMMARY: Further research should focus on defining optimum 25-hydroxy vitamin D levels in pregnancy as well as among various subgroups of the population. Randomized trials are needed to determine whether vitamin D supplementation can improve pregnancy outcomes. Currently, the American College of Obstetrics and Gynecology and the Institute of Medicine recommend 600 IU of daily vitamin D supplementation during pregnancy to support maternal and fetal bone metabolism.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.