ArticleApplied and environmental microbiology2012
BrpA is involved in regulation of cell envelope stress responses in Streptococcus mutans.
Article in Applied and environmental microbiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
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Who cites it
53 citing papers in PubMed, 67 citations in OpenAlex.
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- Antibacterial activity of oregano essential oils against Streptococcus mutans in vitro and analysis of active components.BMC complementary medicine and therapies · 2023Article
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- In vitro anti-biofilm properties of the peel of fruite wall of acorn against Streptococcus mutans.GMS hygiene and infection control · 2023Article
- Fixed Orthodontic Treatment Increases Cariogenicity and Virulence Gene Expression in Dental Biofilm.Journal of clinical medicine · 2022Article
- Proteomic Analysis Reveals Enzymes for β-D-Glucan Formation and Degradation inInternational journal of molecular sciences · 2022Article
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
Previous studies have shown that BrpA plays a major role in acid and oxidative stress tolerance and biofilm formation by Streptococcus mutans. Mutant strains lacking BrpA also display increased autolysis and decreased viability, suggesting a role for BrpA in cell envelope integrity. In this study, we examined the impact of BrpA deficiency on cell envelope stresses induced by envelope-active antimicrobials. Compared to the wild-type strain UA159, the BrpA-deficient mutant (TW14D) was significantly more susceptible to antimicrobial agents, especially lipid II inhibitors. Several genes involved in peptidoglycan synthesis were identified by DNA microarray analysis as downregulated in TW14D. Luciferase reporter gene fusion assays also revealed that expression of brpA is regulated in response to environmental conditions and stresses induced by exposure to subinhibitory concentrations of cell envelope antimicrobials. In a Galleria mellonella (wax worm) model, BrpA deficiency was shown to diminish the virulence of S. mutans OMZ175, which, unlike S. mutans UA159, efficiently kills the worms. Collectively, these results suggest that BrpA plays a role in the regulation of cell envelope integrity and that deficiency of BrpA adversely affects the fitness and diminishes the virulence of OMZ175, a highly invasive strain of S. mutans.
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Registered trials
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